Description

H2N-Peg4-Propyne is a heterobifunctional polyethylene glycol (PEG) linker featuring a primary amine and a terminal alkyne group. This compound is a critical reagent for bioconjugation and click chemistry applications, enabling the precise cross-linking of biomolecules and materials. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics sectors who require reliable, high-purity linkers for developing novel therapeutics, diagnostic probes, and advanced biomaterials.

Application

• Bioconjugation and Protein Labeling: The amine group facilitates covalent attachment to carboxylates or other reactive sites on proteins, antibodies, or peptides, while the alkyne enables subsequent click chemistry modifications.
• ADC (Antibody-Drug Conjugate) Development: Serves as a versatile linker for connecting cytotoxic payloads to monoclonal antibodies via controlled, site-specific conjugation strategies.
• PEGylation and Drug Delivery: Used to PEGylate therapeutic molecules, improving their solubility, stability, and pharmacokinetic profiles while providing a handle for further functionalization.
• Surface Functionalization and Material Science: Employed to modify surfaces (e.g., nanoparticles, chips, polymers) with amine or alkyne functionalities for creating bioactive interfaces.
• Click Chemistry Reagent: The terminal alkyne group participates in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, a cornerstone of bioorthogonal chemistry for labeling and assembly.
• Diagnostic Probe Synthesis: A key building block for constructing fluorescent, radioactive, or other tagged probes used in imaging and diagnostic assays.
• Cross-linking Agent: Acts as a spacer and cross-linker in hydrogel formation and polymer network synthesis for tissue engineering and controlled release applications.

Basic Information

Product Name	H2N-Peg4-Propyne
CAS No.	1013921-36-2
Molecular Formula	C15H27N1O5
Molecular Weight	301.38 g/mol
Synonyms	Amino-PEG4-propyne; 2,5,8,11-Tetraoxatetradecan-14-yn-1-amine; 17-Amino-4,7,10,13-tetraoxahexadec-15-yn-1-ol; Propargyl-PEG4-amine; Alkyne-PEG4-amine; 4-Aza-7,10,13,16-tetraoxanonadec-18-yn-1-amine; NH2-PEG4-Alkyne; 1-Amino-3,6,9,12-tetraoxapentadec-14-yne
EINECS	Contact for details

Quality Control

Our H2N-Peg4-Propyne is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for sensitive research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) in a dry, cool environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.