Description

Mal-Peg3-Mal is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring maleimide groups at both termini, separated by a triethylene glycol spacer. This compound is essential for creating stable, site-specific bioconjugates, particularly in the development of antibody-drug conjugates (ADCs) and protein-polymer therapeutics. Researchers and process development scientists in the pharmaceutical and biotechnology sectors rely on its defined structure and reactivity to link thiol-containing biomolecules with high efficiency and control.

Application

• Antibody-Drug Conjugate (ADC) Linker: A critical component for constructing stable, cleavable, or non-cleavable linkers between cytotoxic payloads and monoclonal antibodies.
• Protein & Peptide PEGylation: Used for site-specific modification of cysteine residues to enhance pharmacokinetic properties such as solubility and circulation half-life.
• Biomolecule Crosslinking: Facilitates the conjugation of different proteins, peptides, or oligonucleotides for creating bispecific constructs or diagnostic probes.
• Surface Functionalization: Enables the covalent attachment of biomolecules to nanoparticles, biosensors, and other material surfaces via thiol-maleimide chemistry.
• Hydrogel Formation: Serves as a crosslinking agent in the synthesis of biocompatible hydrogels for drug delivery and tissue engineering applications.
• Diagnostic Reagent Synthesis: Employed in the development of enzyme-linked immunosorbent assays (ELISA) and other immunoassay components.

Basic Information

Product Name	Mal-Peg3-Mal
CAS No.	1008402-47-8
Molecular Formula	C18H26N2O8
Molecular Weight	398.41 g/mol
Synonyms	1,11-Bis(maleimido)-3,6,9-trioxaundecane; Bis-Maleimide-PEG3; BM(PEG)3; PEG3-bis-maleimide; 3,6,9-Trioxaundecanedioic acid, 1,11-bis(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-; Maleimide-PEG3-Maleimide; 1,1'-(3,6,9-Trioxaundecane-1,11-diyl)bis(1H-pyrrole-2,5-dione)
EINECS	Contact for details

Quality Control

Our Mal-Peg3-Mal is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and process development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.