Description

Hydrocodone-D6 is a deuterated internal standard of the semi-synthetic opioid analgesic hydrocodone, specifically labeled with six deuterium atoms. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analysis in complex biological matrices. It is primarily required by pharmaceutical research laboratories, forensic toxicology units, and contract research organizations (CROs) for use in LC-MS/MS and GC-MS methods.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise quantification of hydrocodone and its metabolites in pharmacokinetic and toxicokinetic studies.
• Forensic Toxicology: Used in the development and validation of analytical methods for the accurate detection of hydrocodone in blood, urine, and other forensic samples.
• Drug Metabolism & Pharmacokinetics (DMPK): Enables reliable measurement of drug concentration-time profiles to support ADME (Absorption, Distribution, Metabolism, and Excretion) studies.
• Clinical Research: Facilitates therapeutic drug monitoring (TDM) and compliance testing in clinical trial settings.
• Method Development & Validation: Provides a stable isotopic reference for optimizing and validating LC-MS/MS and GC-MS analytical procedures, correcting for matrix effects and instrument variability.
• Reference Standard: Acts as a certified reference material (CRM) for calibrating analytical instruments and ensuring method robustness in quality control laboratories.

Basic Information

Product Name	Hydrocodone-D6
CAS No.	1007844-38-3
Molecular Formula	C18H15D6NO3
Molecular Weight	305.4 g/mol (approx.)
Synonyms	4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-one-D6; Dihydrocodeinone-D6; 7,8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6-one-D6; [2H6]-Hydrocodone; Hydrocodone (hexadeuterated); Hydrocodone-d6; Hydrocodone D6; Deuterated Hydrocodone Internal Standard
EINECS	Contact for details

Quality Control

Our Hydrocodone-D6 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity and MS and NMR for isotopic enrichment and structural confirmation, to ensure it meets the exacting standards required for analytical reference materials. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC-MS)	Conforms to structure
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.