Description

m-Peg6-Ss-Peg6-Methyl is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a central disulfide (SS) bond and a terminal methyl group. This compound is engineered to provide a cleavable linkage in bioconjugation and nanomaterial assembly, enabling controlled release under reducing conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications requiring reversible or stimuli-responsive tethering.

Application

• Bioconjugation Reagent: For the reversible attachment of proteins, peptides, or antibodies to surfaces, nanoparticles, or other biomolecules via the cleavable disulfide bridge.
• Drug Delivery Systems: As a key component in the design of smart nanocarriers (e.g., liposomes, micelles) where the disulfide bond is cleaved in the intracellular reducing environment to trigger payload release.
• Surface Functionalization: To create reducible self-assembled monolayers (SAMs) or coatings on gold or other substrates for controlled cell adhesion or release studies.
• Polymer Chemistry: As a cleavable initiator or crosslinking agent in the synthesis of stimuli-responsive hydrogels and polymeric networks.
• Diagnostic Assay Development: In the construction of reversible capture surfaces or probes for ELISA, biosensors, and other diagnostic platforms.
• ADC (Antibody-Drug Conjugate) Linker Exploration: For research into novel linker technologies where controlled drug release is critical for efficacy and safety.

Basic Information

Product Name	m-Peg6-Ss-Peg6-Methyl
CAS No.	1007386-15-3
Molecular Formula	C27H54O13S2
Molecular Weight	650.84 g/mol
Synonyms	1-Methoxy-3,6,9,12,15,18-hexaoxahenicosane-21-thiol 21-(2-{2-[2-(2-{2-[2-(methyloxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethyl) disulfide; Methyl-PEG6-SS-PEG6-methoxy; α-Methyl-ω-(methoxy)-hexa(ethylene glycol) disulfide; Bis(PEG6) disulfide methyl ether; mPEG6-S-S-PEG6-OMe; Heterobifunctional PEG disulfide crosslinker; HS-PEG6-SS-PEG6-OCH3; Cleavable PEG crosslinker
EINECS	Contact for details

Quality Control

Our m-Peg6-Ss-Peg6-Methyl is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This product is hygroscopic and easily oxidized; allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.