Description

3-[2-[2-[(1-Oxo-10-Undecyn-1-Yl)Amino]Ethoxy]Ethoxy]Propanoic Acid 2,5-Dioxo-1-Pyrrolidinyl Ester is a specialized heterobifunctional crosslinking reagent featuring a terminal alkyne and an activated NHS ester, designed for efficient bioconjugation and click chemistry applications. This compound is critical for researchers and manufacturers requiring precise, covalent attachment of biomolecules, polymers, or surfaces under mild aqueous conditions. It is primarily used in the development of advanced pharmaceuticals, diagnostic assays, and novel biomaterials.

Application

• Bioconjugation and Protein Labeling: Covalent attachment of peptides, proteins, or antibodies to surfaces, polymers, or other biomolecules via the activated NHS ester and alkyne groups.
• Click Chemistry Reagent: Acts as a key linker in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for creating complex molecular architectures.
• Polymer Functionalization: Modification of polymer backbones to introduce bio-active sites or alter material properties for biomedical applications.
• Surface Immobilization: Crafting functionalized surfaces for biosensors, microarrays, and diagnostic platforms.
• Antibody-Drug Conjugate (ADC) Development: Serving as a linker-payload component for constructing targeted cancer therapeutics.
• Proteomics Research: Tool for crosslinking studies, activity-based protein profiling, and mapping protein-protein interactions.
• Nanoparticle and Liposome Modification: Functionalizing nanocarriers for targeted drug delivery systems.
• Hydrogel Synthesis: Crosslinking agent for creating tunable, biocompatible hydrogel networks for tissue engineering.

Basic Information

Product Name	3-[2-[2-[(1-Oxo-10-Undecyn-1-Yl)Amino]Ethoxy]Ethoxy]Propanoic Acid 2,5-Dioxo-1-Pyrrolidinyl Ester
CAS No.	1006592-59-1
Molecular Formula	C22H32N2O7
Molecular Weight	436.50 g/mol
Synonyms	10-Undecynoic acid, 11-[(2,5-dioxo-1-pyrrolidinyl)oxy]-2,5,8,11-tetraoxa-14-azapentadec-14-en-15-oic acid, 15-oxo-; NHS-PEG3-Alkyne; Alkyne-PEG3-NHS ester; N-(3-(2-(2-(10-Undecynamido)ethoxy)ethoxy)propyl)-2,5-dioxopyrrolidine-1-carboxamide; Heterobifunctional PEG crosslinker, NHS-PEG3-Alkyne; Alkyne-PEG-tri-NHS ester; PEG-based alkyne NHS ester linker.
EINECS	Contact for details

Quality Control

Our production of 3-[2-[2-[(1-Oxo-10-Undecyn-1-Yl)Amino]Ethoxy]Ethoxy]Propanoic Acid 2,5-Dioxo-1-Pyrrolidinyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive research and development applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group integrity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and hydrolysis. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay (NHS Ester)	≥ 90% active
Functional Group Assay (Alkyne)	≥ 90% active

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.