Description

Lovastatin-D9 is a high-purity, deuterium-labeled internal standard of the cholesterol-lowering agent Lovastatin, essential for ensuring accuracy and reliability in quantitative analytical methods. This stable isotope-labeled compound is critical for researchers and quality control laboratories requiring precise measurements in complex biological matrices. It is primarily used in pharmaceutical research, bioanalytical method development, and clinical metabolism studies where trace-level quantification is paramount.

Application

• Bioanalytical Method Development: Serves as a critical internal standard for the accurate quantification of Lovastatin and its metabolites in plasma, serum, and tissue samples using LC-MS/MS.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Pharmaceutical Quality Control (QC): Used in validated analytical methods to ensure the potency, purity, and consistency of Lovastatin active pharmaceutical ingredients (APIs) and finished dosage forms.
• Stable Isotope Dilution Assays: Provides the foundation for highly accurate and sensitive assays that correct for sample preparation losses and instrument variability.
• Forensic and Doping Analysis: Supports the identification and quantification of statins in forensic toxicology and anti-doping control programs.
• Reference Material for Certification: Acts as a certified reference material (CRM) for calibrating analytical instruments and validating testing procedures in accredited laboratories.

Basic Information

Item	Detail
Product Name	Lovastatin-D9
CAS No.	1002346-03-3
Molecular Formula	C24H27D9O5
Molecular Weight	413.56 g/mol (for C24H27D9O5)
Synonyms	Mevinolin-d9; Monacolin K-d9; 6α-Methylcompactin-d9; [2S-[2α(R*),4aβ,8aα]]-1,2,3,4,4a,5,6,7,8,8a-Decahydro-β,δ-dihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid-d9; (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate-d9; MK-803-d9; Lovalord®-d9 (labeled variant)
EINECS	Contact for details

Quality Control

Every batch of Lovastatin-D9 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing performed using advanced techniques including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the deuterium enrichment, chemical purity, and absence of unlabeled impurities. Our quality commitment supports compliance with GMP/GLP principles for research and analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere to maintain optimal purity and stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium enrichment)	≥ 98 atom % D
Chemical Purity (by HPLC)	≥ 99.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.