Description

Simvastatin, 1-Pyreneacetyl Ester CAS NO 193682-18-7 is a high-purity, chemically modified derivative of the widely used cholesterol-lowering agent, Simvastatin. This compound is of significant value as a key intermediate or reference standard in advanced pharmaceutical research and development. It is primarily needed by R&D chemists and analytical scientists in the pharmaceutical and biotechnology industries for metabolic studies, impurity profiling, and the synthesis of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel statin analogs and prodrugs for cardiovascular research.
• Analytical Reference Standard: Used for method development, validation, and quality control in HPLC and LC-MS analysis of Simvastatin and related compounds.
• Metabolic Pathway Studies: Employed as a tool compound to investigate the metabolic fate and enzymatic interactions of statin drugs.
• Biochemical Research: Utilized in studies targeting HMG-CoA reductase inhibition and cholesterol biosynthesis pathways.
• Fluorescent Labeling Probe: The pyreneacetyl moiety can be exploited for developing fluorescent probes or tags for bioimaging and binding assays.

Basic Information

Product Name	Simvastatin, 1-Pyreneacetyl Ester
CAS No.	193682-18-7
Molecular Formula	C43H54O6
Molecular Weight	666.89 g/mol
Synonyms	1-Pyreneacetic Acid, 2,2-Dimethylbutanoate Ester with (4R,6R)-6-[2-[(1S,2S,6R,8S,8aR)-1,2,6,7,8,8a-Hexahydro-8-hydroxy-2,6-dimethyl-1-naphthalenyl]ethyl]tetrahydro-4-hydroxy-2H-pyran-2-one; Simvastatin Pyreneacetyl Ester; 1-Pyreneacetyl Simvastatin; (4R,6R)-6-[(1S,2S,6R,8S,8aR)-8-(2,2-Dimethylbutanoyloxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl]ethyl]-4-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one 1-Pyreneacetate
EINECS	Contact for details

Quality Control

Our Simvastatin, 1-Pyreneacetyl Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on dried basis)
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.