Description

n-[4-[3-(2,6-Diamino-1,4-Dihydro-4-Oxo-5-Pyrimidinyl)-3-Oxopropyl]Benzoyl]-L-Glutamic Acid is a high-purity, non-natural folate analog with significant research and pharmaceutical development potential. This compound matters as a key intermediate in the synthesis of novel therapeutic agents, particularly in the fields of oncology and metabolic disease research. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced medicinal chemistry and biochemical studies.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel antifolate drugs and targeted cancer therapies.
• Biochemical Research: Used as a tool compound in enzymatic studies, particularly those involving folate-dependent enzymes and pathways.
• Medicinal Chemistry: Serves as a scaffold for structure-activity relationship (SAR) studies to develop new inhibitors.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Preclinical Development: Utilized in the early-stage development of potential therapeutic candidates targeting specific metabolic processes.

Basic Information

Product Name	n-[4-[3-(2,6-Diamino-1,4-Dihydro-4-Oxo-5-Pyrimidinyl)-3-Oxopropyl]Benzoyl]-L-Glutamic Acid
CAS No.	193281-05-9
Molecular Formula	C19H21N5O7
Molecular Weight	431.40 g/mol
Synonyms	5-[3-[4-[(1S)-1,5-Dicarboxypentyl]carbamoyl]phenyl]propionyl]-2,6-diaminopyrimidin-4-one; L-Glutamic acid, N-[4-[3-(2,6-diamino-1,4-dihydro-4-oxo-5-pyrimidinyl)-3-oxopropyl]benzoyl]-; Folate analog intermediate; Pteroic acid glutamic acid derivative; Non-natural folate precursor
EINECS	Contact for details

Quality Control

Our n-[4-[3-(2,6-Diamino-1,4-Dihydro-4-Oxo-5-Pyrimidinyl)-3-Oxopropyl]Benzoyl]-L-Glutamic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.