Description

C6 Biotin Ceramide (D18:1/6:0) is a high-purity, synthetic sphingolipid derivative where a biotin moiety is attached via a six-carbon linker to the ceramide backbone. This compound is a critical reagent for the specific labeling, isolation, and study of ceramide-rich membrane domains and lipid trafficking pathways. It is essential for researchers and manufacturers in the life sciences sector, particularly those developing advanced diagnostic tools, targeted drug delivery systems, and conducting fundamental cell biology research on lipid rafts and signaling.

Application

• Biomembrane Research: As a vital tool for labeling and visualizing sphingolipid-enriched membrane microdomains (lipid rafts) in live-cell and fixed-cell imaging studies.
• Protein-Lipid Interaction Studies: Used to pull down and identify proteins that specifically bind to ceramide or biotinylated lipids via streptavidin-based affinity purification.
• Drug Delivery System Development: Incorporated into liposomal or nanoparticle formulations to create targeted delivery vehicles that can be tracked and anchored using the biotin-streptavidin interaction.
• Diagnostic Assay Development: Serves as a key component in developing assays to detect enzymes involved in sphingolipid metabolism (e.g., ceramidases, sphingomyelinases).
• Cell Signaling Pathway Analysis: Employed to investigate the role of ceramide in apoptosis, cell senescence, and stress response pathways.
• Model Membrane Systems: Used in the construction of artificial lipid bilayers and vesicles to study membrane biophysics and organization.

Basic Information

Product Name	C6 Biotin Ceramide (D18:1/6:0)
CAS No.	192070-02-3
Molecular Formula	C48H89N3O6S
Molecular Weight	836.31 g/mol
Synonyms	N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]hexanamide, 6-[(5-[(3aS,4S,6aR)-2-Oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoyl)amino]; Biotinyl-C6-Ceramide; D-erythro-C6-Biotinoyl Ceramide (d18:1/6:0); Biotinylated C6-Ceramide; N-Hexanoyl-D-erythro-sphingosine Biotinylamide; N-Caproyl-D-erythro-sphingosine Biotinylamide; Biotin Caproyl Ceramide
EINECS	Contact for details

Quality Control

Our C6 Biotin Ceramide is produced under strict quality management protocols to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, ethanol, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.