Description

H-Val-Amc Tfa is a protected amino acid derivative, specifically the trifluoroacetate salt of H-Valine amide. This high-purity building block is critical for the synthesis of complex peptides and peptidomimetics, offering excellent control over stereochemistry and reaction pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled elongation of peptide chains.
• Pharmaceutical Research: Serves as a crucial building block in the discovery and development of novel therapeutic peptides.
• Process Chemistry: Used in the scale-up and optimization of API manufacturing processes requiring valine incorporation.
• Bioconjugation: Employed in the synthesis of peptide-based linkers for antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology: A valuable tool for probing enzyme-substrate interactions and designing enzyme inhibitors.
• Custom Peptide Services: Supplied to CROs and CDMOs for the production of bespoke peptide sequences for clients.

Basic Information

Product Name	H-Val-Amc Tfa
CAS No.	191723-67-8
Molecular Formula	C8H15F3N2O3
Molecular Weight	244.21 g/mol
Synonyms	L-Valinamide, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-; Fmoc-Val-NH2 TFA salt; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valinamide trifluoroacetate; Fmoc-L-Val-NH2·TFA; Fmoc-Valinamide TFA; N-Fmoc-L-valinamide trifluoroacetate; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanamide trifluoroacetate
EINECS	Contact for details

Quality Control

Our H-Val-Amc Tfa is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and pharmaceutical intermediates, with specifications tailored to meet the rigorous demands of research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.