Description

H-Ile-Amc Tfa is a specialized protected amino acid derivative, widely utilized as a critical building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates to ensure the fidelity and yield of complex peptide sequences. It is primarily used by the pharmaceutical, biotechnology, and life sciences industries for applications in drug discovery, proteomics research, and the development of therapeutic peptides.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of isoleucine residues into peptide chains.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Protease Substrate Development: Serves as a fluorogenic substrate component for studying enzyme kinetics and activity, particularly for proteases.
• Bioconjugation & Labeling: Acts as a precursor for creating labeled peptides used in diagnostic assays and imaging.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening.
• Academic & Industrial Research: A fundamental reagent in biochemical and medicinal chemistry laboratories for exploring protein-protein interactions and signal transduction pathways.

Basic Information

Product Name	H-Ile-Amc Tfa
CAS No.	191723-53-2
Molecular Formula	C15H17F3N2O4
Molecular Weight	346.30 g/mol
Synonyms	H-Ile-AMC TFA; Isoleucine-7-amido-4-methylcoumarin Trifluoroacetate; L-Isoleucine 7-amido-4-methylcoumarin TFA salt; Ile-AMC TFA; 7-Amido-4-methylcoumarin-Ile TFA; AMC-Ile TFA; N-(tert-Butoxycarbonyl)-L-isoleucyl-7-amido-4-methylcoumarin TFA (related protected form); Protease Substrate Ile-AMC
EINECS	Contact for details

Quality Control

Our H-Ile-Amc Tfa is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP guidelines, as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.