Description

(Benzotriazol-1-yloxy)dipiperidinocarbenium hexafluorophosphate is a highly reactive peptide coupling reagent, widely recognized as HBPyU. It is a critical component for facilitating efficient amide bond formation in complex organic synthesis, particularly in peptide and pharmaceutical manufacturing. This reagent is essential for researchers and production chemists in the pharmaceutical, biotechnology, and advanced materials sectors who require high-yield, low-racemization coupling reactions.

Application

• Peptide Synthesis: A powerful coupling agent for solid-phase and solution-phase peptide synthesis, minimizing epimerization.
• Pharmaceutical Intermediates: Key for constructing amide bonds in the synthesis of active pharmaceutical ingredients (APIs) and complex drug candidates.
• Bioconjugation: Used in the labeling and modification of proteins, antibodies, and other biomolecules.
• Polymer Chemistry: Employed in the synthesis of polyamides and other specialty polymers requiring precise amide linkages.
• Chemical Research & Development: A versatile tool for academic and industrial R&D labs exploring new synthetic methodologies.
• Agrochemical Synthesis: Facilitates the production of certain herbicides and fungicides that contain amide functional groups.

Basic Information

Product Name	(Benzotriazol-1-yloxy)dipiperidinocarbenium Hexafluorophosphate
CAS No.	190849-64-0
Molecular Formula	C22H31F6N6OP
Molecular Weight	540.49 g/mol
Synonyms	HBPyU; 1-(Benzotriazol-1-yloxy)dipiperidinocarbenium Hexafluorophosphate; Benzotriazol-1-yloxytripyrrolidinophosphonium Hexafluorophosphate (common misnomer); BOP Reagent Analog; Coupling Reagent HBPyU; 1-Hydroxybenzotriazole Dipiperidinocarbenium Salt; PyU; (1H-Benzotriazol-1-yloxy)dipiperidinocarbenium Hexafluorophosphate
EINECS	Contact for details

Quality Control

Our (Benzotriazol-1-yloxy)dipiperidinocarbenium hexafluorophosphate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.