Description

(S)-Meclizine CAS NO 189298-47-3 is the single enantiomer form of the well-known antihistamine and antiemetic agent, meclizine. This specific stereoisomer is of significant interest in advanced pharmaceutical research and development for its potential to offer improved pharmacological profiles, such as enhanced efficacy or reduced side effects, compared to the racemic mixture. It is primarily utilized by pharmaceutical companies and research institutions engaged in the synthesis of novel chiral drugs, targeted therapies, and for conducting detailed pharmacological studies.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key chiral building block in the synthesis of enantiomerically pure pharmaceutical compounds.
• Pharmacological Research: Used in preclinical and clinical studies to investigate the specific biological activity and metabolic pathways of the (S)-enantiomer.
• Chiral Reference Standard: Serves as a high-purity standard for analytical method development and validation in quality control laboratories.
• Asymmetric Synthesis: Employed in academic and industrial research focused on developing new catalytic asymmetric reactions.
• Formulation Development: Used in the development of specialized drug delivery systems for targeted or sustained-release applications.

Basic Information

Product Name	(S)-Meclizine
CAS No.	189298-47-3
Molecular Formula	C25H27ClN2
Molecular Weight	390.95 g/mol
Synonyms	(S)-1-[(4-Chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine; (S)-Meclizine; (S)-Meclozine; (S)-Postafen; (S)-Bonamine; (S)-Antivert; (S)-Histamethizine; (S)-Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-, (S)-
EINECS	Contact for details

Quality Control

Our (S)-Meclizine is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity determination, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.