Description

1,4-Dimaleimido-2,3-Butanediol is a high-purity, heterobifunctional crosslinking agent featuring maleimide and hydroxyl functional groups. This compound is critical for creating stable covalent linkages in advanced material science and bioconjugation applications, enabling precise molecular architecture. It is primarily utilized by researchers and manufacturers in the pharmaceutical, polymer, and life science sectors for developing drug delivery systems, functionalized polymers, and diagnostic reagents.

Application

• Bioconjugation and Protein Modification: Used to create stable thioether bonds between maleimide groups and cysteine residues in antibodies, peptides, or enzymes for ADC (Antibody-Drug Conjugate) development and protein labeling.
• Polymer Crosslinking and Functionalization: Serves as a key monomer or crosslinker in the synthesis of hydrogels, responsive polymers, and networks with tailored mechanical and chemical properties.
• Surface Immobilization Chemistry: Enables the covalent attachment of biomolecules or polymers to surfaces (e.g., chips, nanoparticles, beads) via the hydroxyl group for biosensor and diagnostic assay platforms.
• Linker for Small Molecule Prodrugs: Acts as a cleavable or stable linker in the design of targeted prodrugs and therapeutic conjugates.
• Material Science Research: Employed in R&D for developing novel smart materials, self-healing polymers, and advanced composites with specific crosslink densities.
• Diagnostic Reagent Synthesis: Utilized in the manufacture of fluorescent or enzyme-labeled probes and other diagnostic components requiring stable covalent linkages.

Basic Information

Product Name	1,4-Dimaleimido-2,3-Butanediol
CAS No.	189013-00-1
Molecular Formula	C12H10N2O6
Molecular Weight	278.22 g/mol
Synonyms	2,3-Bis(hydroxymethyl)-1,4-bis(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)butane; 1,4-Bis(maleimido)-2,3-butanediol; 2,3-Dihydroxybutane-1,4-diyl bis(2,5-dihydro-1H-pyrrole-2,5-dione); 1,4-Dimaleimidobutane-2,3-diol; Bifunctional Maleimide Crosslinker; Heterobifunctional Maleimide Linker; 1,4-Dimaleimido-2,3-dihydroxybutane
EINECS	Contact for details

Quality Control

Our 1,4-Dimaleimido-2,3-Butanediol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed in a desiccated environment to prevent degradation. For long-term storage under an inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.