Description

L-α-D-Myo-Phosphatidylinositol-3,4-Diphosphate is a high-purity, synthetic phospholipid derivative, specifically a phosphorylated phosphatidylinositol (PI) signaling molecule. This compound is a critical second messenger in cellular signal transduction pathways, primarily involved in regulating cell growth, proliferation, and survival. It is an essential biochemical tool for pharmaceutical research, cell biology studies, and the development of assays targeting the PI3K/Akt/mTOR signaling network.

Application

• Biochemical Research: Used as a standard, substrate, or ligand in enzymatic studies of phosphoinositide kinases (PI3K, PI4K) and phosphatases (PTEN, SHIP).
• Cell Signaling Studies: Critical for investigating intracellular signaling cascades, particularly those involving Akt/PKB activation and downstream effects on apoptosis and metabolism.
• Drug Discovery & Screening: Serves as a key component in high-throughput screening (HTS) assays to identify and characterize novel inhibitors of PI3K and related pathway targets for oncology and metabolic diseases.
• Lipidomics & Analytical Standards: Employed as a certified reference material in mass spectrometry-based lipidomic profiling to quantify endogenous PI(3,4)P2 levels in biological samples.
• Membrane Biophysics: Used in model membrane systems (e.g., liposomes, lipid bilayers) to study protein-lipid interactions and membrane recruitment domains, such as PH domains.
• Diagnostic Development: Potential use in developing diagnostic tools for diseases with dysregulated phosphoinositide signaling.

Basic Information

Product Name	L-α-D-Myo-Phosphatidylinositol-3,4-Diphosphate
CAS No.	188885-38-3
Molecular Formula	C47H88O19P3 (for common diacyl forms, e.g., PI(3,4)P2 (18:0/20:4))
Molecular Weight	~1049.10 g/mol (Formula-dependent)
Synonyms	PI(3,4)P2; Phosphatidylinositol 3,4-bisphosphate; PtdIns(3,4)P2; 1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate; D-myo-Inositol, 1-(1,2-di-O-octadec-9-enoyl-sn-glycero-3-O-phosphonato)-, 3,4-bis(dihydrogen phosphate) (stereoisomer); Phosphoinositide(3,4)P2; PtdIns(3,4)P₂
EINECS	Contact for details

Quality Control

Our L-α-D-Myo-Phosphatidylinositol-3,4-Diphosphate is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research applications. Each lot is accompanied by comprehensive analytical data, including HPLC purity, mass spectrometry (MS) confirmation, and 1H/31P NMR structural verification. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (MS)	Complies (Negative ion mode)
Identification (NMR)	Complies (1H & 31P spectra)
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform/methanol/water mixtures
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.