Description

1-Palmitoyl-2-Stearoyl-(5-Doxyl)-Sn-Glycero-3-Phosphocholine is a specialized, spin-labeled phospholipid analog designed for advanced biophysical research. This compound matters because it serves as a critical molecular probe for investigating membrane dynamics, structure, and protein-lipid interactions using techniques like Electron Paramagnetic Resonance (EPR) spectroscopy. Research scientists in pharmaceuticals, biochemistry, and biophysics need it to study model lipid bilayers, membrane fluidity, and the mechanistic actions of membrane-associated proteins and drug candidates.

Application

• As a spin-label probe in Electron Paramagnetic Resonance (EPR) spectroscopy for studying membrane bilayer properties.
• Research on model lipid membranes and liposomes to understand phase behavior and lateral organization.
• Investigating membrane fluidity and dynamics in artificial and reconstituted biological systems.
• Probing protein-lipid interactions and the localization of membrane-active peptides or drugs.
• Use in biophysical assays to characterize lipid rafts, domain formation, and membrane curvature.
• Development and calibration of advanced diagnostic or research tools based on EPR signal detection.

Basic Information

Product Name	1-Palmitoyl-2-Stearoyl-(5-Doxyl)-Sn-Glycero-3-Phosphocholine
CAS No.	188004-24-2
Molecular Formula	C₄₅H₈₉NO₈P
Molecular Weight	811.16 g/mol
Synonyms	5-Doxyl PC(16:0/18:0); 1-Palmitoyl-2-stearoyl-sn-glycero-3-phospho(tempo)choline; 16:0-18:0 Tempocholine; 5-DOXYL Phosphatidylcholine; Spin-labeled phosphatidylcholine; EPR probe lipid; 5-PCSL; 1-Palmitoyl-2-stearoyl-phosphatidylcholine tempoyl
EINECS	Contact for details

Quality Control

Our 1-Palmitoyl-2-Stearoyl-(5-Doxyl)-Sn-Glycero-3-Phosphocholine is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes rigorous analytical testing, including HPLC and spectroscopic methods, to verify identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive; allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and exposure to air and moisture.

Specification

Item	Specification
Appearance	Yellow to orange waxy solid or film
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95% (Area %)
Assay (EPR active probe)	≥ 90%
Solubility	Soluble in chloroform, ethanol; forms vesicles in aqueous buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.