Description

o-(2-Aminoethyl)-O'-(2-Carboxyethyl)Polyethylene Glycol Hydrochloride is a heterobifunctional polyethylene glycol (PEG) derivative, a crucial building block for advanced bioconjugation and surface modification. This compound matters because it provides orthogonal reactive groups—a primary amine and a carboxylic acid—enabling controlled, sequential coupling to biomolecules and materials. It is essential for researchers and manufacturers in the pharmaceutical, diagnostics, and biomaterials sectors who require precise, reproducible linker chemistry for creating PEGylated therapeutics, functionalized nanoparticles, and hydrogel networks.

Application

• Bioconjugation Linker: For the site-specific PEGylation of peptides, proteins, and antibodies to improve solubility, stability, and pharmacokinetics.
• Surface Functionalization: To introduce amine or carboxyl groups onto nanoparticles, quantum dots, and biosensor surfaces for subsequent biomolecule immobilization.
• Crosslinking Agent: In the synthesis of hydrogels and polymer networks for tissue engineering and drug delivery systems.
• Diagnostic Reagent Synthesis: As a spacer arm in the development of immunoassay components and fluorescent probes to reduce steric hindrance.
• Affinity Chromatography Media: For coupling ligands to solid supports to create customized purification resins.
• Polymer Chemistry: As a macroinitiator or monomer for synthesizing functional, biocompatible block copolymers.

Basic Information

Product Name	o-(2-Aminoethyl)-O'-(2-Carboxyethyl)Polyethylene Glycol Hydrochloride
CAS No.	187848-66-4
Molecular Formula	C2n+6H4n+14NOn+2Cl (n = PEG repeat units)
Molecular Weight	Variable, dependent on PEG chain length (e.g., 1kDa, 2kDa, 5kDa, 10kDa, 20kDa). Contact for details.
Synonyms	H2N-PEG-COOH · HCl; Amino-PEG-Acid Hydrochloride; α-Amino-ω-carboxy PEG Hydrochloride; Amine-PEG-Carboxylic Acid HCl; PEG-bis(amine/carboxylic acid) HCl; Heterobifunctional PEG HCl Salt; 2-Aminoethyl-2-carboxyethyl PEG Ether Hydrochloride; Poly(ethylene glycol) bis(2-aminoethyl, 2-carboxyethyl) ether hydrochloride
EINECS	Contact for details.

Quality Control

Our o-(2-Aminoethyl)-O'-(2-Carboxyethyl)Polyethylene Glycol Hydrochloride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and functional group analysis, to ensure consistency and performance for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications for molecular weight, polydispersity, and functional group content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (cold chain) or as specified on the label. This product is hygroscopic (moisture-sensitive). For long-term stability, store desiccated at -20°C under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder or waxy solid
Identification (IR)	Conforms to structure
PEG Average Molecular Weight	As ordered (e.g., 1,000 Da, 2,000 Da, 5,000 Da)
Polydispersity Index (PDI)	≤ 1.05 (by GPC)
Assay (Functional Groups)	≥ 95% (by NMR/Titration)
Amine Content	As per COA (µmol/g)
Carboxylic Acid Content	As per COA (µmol/g)
Solubility	Soluble in water, DMSO, DMF
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.