Description

1,6,7,8-Indolizinetetrol, Octahydro-1-Methyl-, 1S-(1.Alpha.,6.Beta.,7.Alpha.,8.Beta.,8A.Beta.)- is a complex, stereochemically defined polyhydroxylated indolizidine derivative. This compound is of significant interest as a high-purity synthetic intermediate and a key scaffold in advanced organic synthesis. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, glycosidase inhibitors, and chiral building blocks for complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of potential drug candidates targeting metabolic and neurological disorders.
• Glycosidase Inhibitor Research: The polyhydroxylated indolizidine core structure is a hallmark of compounds studied for enzyme inhibition, relevant in diabetes and antiviral research.
• Chemical Biology Probe Development: Used to create molecular tools for studying carbohydrate-processing enzymes and cellular pathways.
• Asymmetric Synthesis: Acts as a sophisticated chiral template or starting material for the construction of enantiomerically pure natural product analogs.
• Academic & Industrial R&D: Employed in exploratory chemistry for developing new synthetic methodologies and discovering bioactive molecules.

Basic Information

Product Name	1,6,7,8-Indolizinetetrol, Octahydro-1-Methyl-, 1S-(1.Alpha.,6.Beta.,7.Alpha.,8.Beta.,8A.Beta.)-
CAS No.	185899-46-1
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	(1S,6R,7R,8R,8aR)-Octahydro-1-methyl-1,6,7,8-indolizinetetrol; 1-Deoxymannojirimycin derivative; Polyhydroxylated Indolizidine; 1-Methyl-DMJ; (1S,6R,7R,8R,8aR)-1-Methyloctahydroindolizine-1,6,7,8-tetrol; Chiral Indolizidine Tetrol; CAS 185899-46-1
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, identity, and stereochemical integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.