Description

Fmoc-Asp-Pna CAS NO 185547-52-8 is a protected aspartic acid derivative, specifically an Fmoc-protected aspartic acid para-nitroanilide, widely used as a key building block in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity, sequence-specific peptide intermediates for pharmaceutical and biochemical applications. It is essential for the development of peptide-based therapeutics, diagnostic reagents, and research tools in biotechnology and medicinal chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a crucial protected amino acid derivative for the controlled incorporation of aspartic acid into peptide chains.
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs) for peptide drugs targeting metabolic disorders, cancer, and infectious diseases.
• Protease Substrate Synthesis: Acts as a precursor for synthesizing chromogenic and fluorogenic substrates used to assay protease enzyme activity (e.g., Caspase, Thrombin).
• Biochemical Research: Employed in academic and industrial R&D for studying protein-protein interactions, enzyme kinetics, and signal transduction pathways.
• Combinatorial Chemistry Libraries: A valuable reagent for generating diverse peptide libraries for high-throughput screening in drug discovery.
• Custom Peptide Services: A fundamental raw material for CROs and CDMOs offering custom peptide synthesis services.

Basic Information

Product Name	Fmoc-Asp-Pna
CAS No.	185547-52-8
Molecular Formula	C29H27N3O7
Molecular Weight	529.54 g/mol
Synonyms	Fmoc-Asp(OtBu)-pNA; Fmoc-L-Aspartic acid 4-(tert-butyl) ester 4-nitroanilide; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-aspartic acid 1-(4-nitroanilide) 4-tert-butyl ester; Fmoc-Asp(OtBu)-p-nitroanilide; Fmoc-Aspartic acid β-tert-butyl ester p-nitroanilide; Fmoc-Asp(OtBu)-4-nitroanilide; Nα-Fmoc-Nβ-tert-butyl-L-aspartyl-4-nitroanilide
EINECS	Contact for details

Quality Control

Our Fmoc-Asp-Pna is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to verify enantiomeric purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-20.0° to -24.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.