Description

2'-Tbdms-Bz-Rc CAS NO 185398-21-4 is a high-purity, protected nucleoside derivative used as a critical building block in oligonucleotide synthesis. This compound is essential for the development of antisense oligonucleotides, siRNA, and other advanced therapeutic nucleic acids, where precise chemical modification is required for stability and efficacy. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and CDMOs specializing in nucleic acid-based drug discovery and manufacturing.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key phosphoramidite precursor for the automated synthesis of modified DNA/RNA strands.
• Antisense Oligonucleotide (ASO) Development: Used to create therapeutic oligonucleotides targeting specific mRNA sequences for genetic disorders and oncology.
• Small Interfering RNA (siRNA) Production: Enables the incorporation of modified nucleosides to enhance siRNA stability, potency, and pharmacokinetic properties.
• Research & Diagnostic Probes: Serves as a raw material for synthesizing labeled probes used in genomics, molecular diagnostics, and bioanalytical assays.
• Pharmaceutical Intermediates: Acts as a vital intermediate in the multi-step synthesis of novel nucleoside-based active pharmaceutical ingredients (APIs).
• Academic & Industrial R&D: Supports fundamental research in nucleic acid chemistry, biochemistry, and medicinal chemistry.

Basic Information

Product Name	2'-Tbdms-Bz-Rc
CAS No.	185398-21-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	2'-O-(tert-Butyldimethylsilyl)-5'-O-(4,4'-Dimethoxytrityl)-N-benzoyl-cytidine 3'-(2-Cyanoethyl N,N-diisopropylphosphoramidite); 2'-TBDMS-C(Bz)-CE Phosphoramidite; 2'-O-TBDMS-N4-Benzoylcytidine-3'-CE Phosphoramidite; 2'-O-TBDMS-C(Bz) Phosphoramidite; 2'-TBDMS-C(Bz) Phosphoramidite; N4-Benzoyl-2'-O-(tert-butyldimethylsilyl)cytidine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite); 5'-O-DMT-2'-O-TBDMS-N4-benzoylcytidine-3'-O-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
EINECS	Contact for details

Quality Control

Our 2'-Tbdms-Bz-Rc is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing specific test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. For long-term storage, consider storing at -20°C under desiccant.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility Test	Freely soluble in anhydrous acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.