Description

8-Chloroadenosine-5'-o-Triphosphate Sodium Salt is a chemically modified nucleotide analog where a chlorine atom is substituted at the 8-position of the adenine ring. This modification is critical for its role as a potent inhibitor of ATP-dependent enzymes, making it a valuable tool compound in biochemical research. It is primarily utilized by researchers in enzymology, molecular biology, and medicinal chemistry for studying kinase activity, signal transduction pathways, and developing enzyme inhibitors.

Application

• Enzyme Inhibition Studies: Used as a substrate analog to investigate the mechanism and kinetics of ATP-dependent enzymes, particularly kinases and ATPases.
• Biochemical Research: Serves as a critical reagent in assays designed to screen for and characterize novel enzyme inhibitors in drug discovery pipelines.
• Signal Transduction Pathway Analysis: Employed to probe and modulate cellular signaling cascades that rely on ATP hydrolysis or phosphorylation events.
• Structural Biology: Can be used in crystallography or NMR studies to determine enzyme-inhibitor complex structures.
• Medicinal Chemistry Reference Standard: Acts as a benchmark compound for the synthesis and evaluation of new nucleoside triphosphate analogs with therapeutic potential.

Basic Information

Product Name	8-Chloroadenosine-5'-o-Triphosphate Sodium Salt
CAS No.	185341-71-3
Molecular Formula	C10H12ClN5O13P3·xNa
Molecular Weight	Approx. 605.7 (Free acid)
Synonyms	8-Cl-ATP Sodium Salt; 8-Chloro-ATP; 8-Chloroadenosine 5'-(tetrahydrogen triphosphate) sodium salt; Adenosine-5'-triphosphate, 8-chloro-, sodium salt; 8-Chloro-adenosine-5'-triphosphate; ATP, 8-chloro-, sodium salt; 8-Chloro-ATP-Na
EINECS	Contact for details

Quality Control

Our 8-Chloroadenosine-5'-o-Triphosphate Sodium Salt is produced under stringent quality control protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.