Description

Sulfo-n-Succinimidyl 4-Maleimidobutyrate Sodium Salt is a heterobifunctional crosslinking reagent designed for the conjugation of biomolecules. Its core value lies in its dual functionality, featuring an amine-reactive NHS ester and a sulfhydryl-reactive maleimide group, enabling the stable and site-specific coupling of proteins, peptides, and other ligands. This compound is essential for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and diagnostic assay kit production, where creating defined molecular constructs is critical.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: A key reagent for covalently attaching cytotoxic drugs to monoclonal antibodies via lysine residues.
• Protein-Protein and Protein-Peptide Conjugation: Facilitates the creation of stable complexes for structural studies, immunoassays, and therapeutic protein engineering.
• Immobilization of Biomolecules: Used to attach proteins or peptides to solid surfaces (e.g., sensor chips, microplates, beads) for biosensor development and affinity chromatography.
• Fluorescent and Enzymatic Labeling: Enables the site-specific labeling of antibodies and other proteins with reporter molecules for imaging and diagnostic applications.
• Polymer Modification: Functionalizes polymers with bioactive molecules for targeted drug delivery systems and biomaterial fabrication.
• Diagnostic Reagent Manufacturing: Critical in producing conjugated antigens and antibodies used in ELISA, lateral flow assays, and other clinical diagnostics.

Basic Information

Product Name	Sulfo-n-Succinimidyl 4-Maleimidobutyrate Sodium Salt
CAS No.	185332-92-7
Molecular Formula	C13H13N2NaO9S
Molecular Weight	396.30 g/mol
Synonyms	Sulfo-SMCC Sodium Salt; 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic acid 3-sulfo-N-hydroxysuccinimide ester sodium salt; Sodium 4-[(2,5-dioxopyrrol-1-yl)oxy]-4-oxobutylmaleimide-1-sulfonate; SMCC Sulfo-NHS ester; NHS-PEG4-Maleimide (sulfonated); Heterobifunctional Crosslinker, Sulfo-SMCC; Maleimide-PEG4-NHS Ester (sulfonated); 185332-92-7
EINECS	Contact for details

Quality Control

Our Sulfo-n-Succinimidyl 4-Maleimidobutyrate Sodium Salt is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, identity, and functional suitability. We support compliance with relevant GMP and ISO 9001 standards for traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0 %
Solubility	Soluble in water, DMSO
Functional Activity	Conforms (by conjugation test)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.