Description

n-Hydroxysuccinimidyl-trans-4-Isopropylcyclohexanecarboxylate is a high-purity, activated ester reagent used for the covalent conjugation of biomolecules. Its value lies in its role as a versatile linker for introducing the lipophilic trans-4-isopropylcyclohexyl moiety, which can modulate the pharmacokinetic properties of peptides, proteins, and other bioactive compounds. This product is essential for researchers and manufacturers in pharmaceutical development, proteomics, and bioconjugation who require reliable, high-quality intermediates for creating novel drug candidates and diagnostic tools.

Application

• Peptide Modification: Conjugation of the lipophilic isopropylcyclohexyl group to peptide N-termini or side chains to enhance membrane permeability and metabolic stability.
• Antibody-Drug Conjugate (ADC) Synthesis: Serving as a key building block for constructing linker-payload complexes in targeted cancer therapies.
• Protein Labeling: Facilitating the site-specific attachment of fluorescent dyes, biotin, or other probes to proteins for imaging and detection assays.
• Prodrug Development: Used to create ester-based prodrugs of carboxylic acid-containing active pharmaceutical ingredients (APIs) to improve solubility or bioavailability.
• Polymer Functionalization: Modification of polymeric materials (e.g., PEG, dendrimers) to introduce bioactive ligands or targeting groups.
• Solid-Phase Synthesis: Incorporation as a protected or activated intermediate in automated peptide and oligonucleotide synthesis.
• Chemical Biology Tool Development: Creation of activity-based probes and affinity tags for studying enzyme function and protein interactions.

Basic Information

Product Name	n-Hydroxysuccinimidyl-trans-4-Isopropylcyclohexanecarboxylate
CAS No.	183997-00-4
Molecular Formula	C14H21NO5
Molecular Weight	283.32 g/mol
Synonyms	NHS-trans-4-Isopropylcyclohexanecarboxylate; N-Hydroxysuccinimide trans-4-Isopropylcyclohexanecarboxylate; trans-4-Isopropylcyclohexanecarboxylic Acid N-Hydroxysuccinimide Ester; 1-[(trans-4-Isopropylcyclohexyl)carbonyloxy]-2,5-pyrrolidinedione; N-Succinimidyl trans-4-Isopropylcyclohexanecarboxylate; 4-Isopropylcyclohexanecarboxylic Acid, trans-, N-Hydroxysuccinimide Ester; NSC 339586
EINECS	Contact for details

Quality Control

Our n-Hydroxysuccinimidyl-trans-4-Isopropylcyclohexanecarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 102.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.