Description

(1,2-Dipalmitoyl)-L-α-Phosphatidyl-D-Myo-Inositol 3,4-Bisphosphate is a high-purity, synthetic phosphatidylinositol phosphate (PIP) lipid, specifically the PI(3,4)P2 isomer. This compound is a critical signaling molecule in cellular processes, serving as a key secondary messenger in pathways regulating cell growth, survival, and membrane trafficking. It is essential for researchers and developers in pharmaceutical discovery, cell biology, and biochemistry, particularly for studying phosphoinositide 3-kinase (PI3K) signaling networks and lipid-protein interactions.

Application

• Biochemical Research: As a standard and substrate for studying enzymes like phosphatidylinositol 3-kinases (PI3Ks), phosphatases (e.g., PTEN, SHIP), and phospholipase C.
• Lipidomics & Cell Signaling: Used in mass spectrometry-based lipidomics to identify and quantify cellular PIP species and investigate downstream effector protein binding (e.g., PH domains).
• Drug Discovery & Screening: Employed in high-throughput assays to screen for inhibitors or activators of PI3K pathway components targeting cancer, immunology, and metabolic diseases.
• Liposome & Membrane Biophysics: Incorporated into synthetic liposomes and lipid bilayers to model specific membrane microdomains and study protein recruitment and membrane dynamics.
• Diagnostic Development: Potential use as a component in diagnostic kits for detecting abnormalities in phosphoinositide metabolism.

Basic Information

Item	Detail
Product Name	(1,2-Dipalmitoyl)-L-α-Phosphatidyl-D-Myo-Inositol 3,4-Bisphosphate
CAS No.	183623-41-8
Molecular Formula	C47H88O19P3
Molecular Weight	1050.10 g/mol
Synonyms	PI(3,4)P2 (16:0/16:0); Dipalmitoyl PI(3,4)P2; 1,2-Dipalmitoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4'-bisphosphate); Phosphatidylinositol 3,4-bisphosphate (dipalmitoyl); PtdIns(3,4)P2; PI-3,4-P2; 3,4-bisphospho-D-myo-inositol 1-(1,2-dihexadecanoyl-sn-glycerol) hydrogen phosphate
EINECS	Contact for details

Quality Control

Our high-purity synthetic lipids are manufactured under strict quality systems. Each batch is characterized using advanced analytical techniques to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing specifications such as assay by HPLC, lipid profile, and absence of critical impurities. We support research and GMP-grade development needs with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and hydrolysis. For long-term storage, keep desiccated at -80°C.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (MS)	Complies
Identification (NMR)	Complies
Purity (HPLC)	≥ 95% (Area %)
Solubility	Soluble in chloroform/methanol/water mixtures
Water Content (KF)	< 1.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.