Description

Tipiracil is a high-purity pharmaceutical intermediate and active ingredient, identified by CAS NO 183204-72-0. It is a critical component in the synthesis of novel anticancer therapeutics, specifically as a potent thymidine phosphorylase inhibitor. This compound is essential for pharmaceutical manufacturers and advanced research institutions developing targeted oncology treatments and combination therapies.

Application

• Pharmaceutical Active Ingredient (API): Primary use as a key component in the formulation of anticancer drugs, such as TAS-102 (trifluridine/tipiracil hydrochloride).
• Oncology Research: Critical reagent in biochemical and pharmacological studies targeting thymidine phosphorylase for cancer cell proliferation inhibition.
• Preclinical & Clinical Development: Used in the development and scale-up of new chemotherapeutic agents and combination regimens.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical production.
• Process Chemistry: Intermediate in the multi-step synthesis of complex, targeted therapeutic molecules.

Basic Information

Product Name	Tipiracil
CAS No.	183204-72-0
Molecular Formula	C9H11ClN2O5
Molecular Weight	262.65 g/mol
Synonyms	5-Chloro-6-[(2-iminopyrrolidin-1-yl)methyl]-2,4(1H,3H)-pyrimidinedione; TPI; Tipiracil Hydrochloride; FTY; TAS-102 (component); 6-((2-Iminopyrrolidin-1-yl)methyl)-5-chlorouracil; 5-Chloro-6-((2-iminopyrrolidin-1-yl)methyl)uracil
EINECS	Contact for details

Quality Control

Our Tipiracil is manufactured under strict quality management systems to meet the exacting standards of the pharmaceutical industry. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by IR and NMR. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.