Description

3-Toluoyl Decitabine is a chemically modified derivative of the nucleoside analog decitabine, designed to enhance its stability and pharmacokinetic profile. This compound is of significant interest in advanced pharmaceutical research and development, particularly for creating novel prodrug formulations. It serves as a critical intermediate for researchers and manufacturers in the oncology and epigenetics fields, enabling the exploration of targeted therapeutic strategies.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside analog prodrugs for enhanced drug delivery.
• Oncology Research: Used in preclinical studies to develop next-generation epigenetic modulators and DNA methyltransferase inhibitors.
• Biochemical Research: Serves as a tool compound for studying enzyme kinetics and metabolic pathways involving modified nucleosides.
• Process Development: Employed in scaling up and optimizing synthetic routes for active pharmaceutical ingredients (APIs) in GMP environments.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medicinal chemistry and chemical biology.

Basic Information

Product Name	3-Toluoyl Decitabine
CAS No.	183016-21-9
Molecular Formula	C18H21N3O5
Molecular Weight	359.38 g/mol
Synonyms	4-Amino-1-(2-deoxy-β-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one 3'-O-(4-methylbenzoyl); 3'-O-(p-Toluoyl)decitabine; 3'-O-(4-Methylbenzoyl)-5-aza-2'-deoxycytidine; 5-Aza-2'-deoxycytidine 3'-(4-methylbenzoate); Decitabine 3'-toluate; 3'-Toluoyl-5-aza-2'-deoxycytidine; p-Toluoyl decitabine
EINECS	Contact for details

Quality Control

Our 3-Toluoyl Decitabine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.