Description

Caspase-4 is a crucial cysteine-aspartic protease enzyme involved in the innate immune response, specifically in the non-canonical inflammasome pathway. Its primary value lies in its role as a key research target for understanding inflammatory diseases, sepsis, and cancer biology. This high-purity biochemical is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors who are investigating novel therapeutic strategies.

Application

• Biochemical Research: Used as a substrate or target enzyme in studies of the inflammasome pathway and pyroptosis.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) assays to identify and characterize potential caspase-4 inhibitors for inflammatory conditions.
• Diagnostic Development: Serves as a key component in developing diagnostic kits for detecting specific inflammatory biomarkers.
• Cell Biology Studies: Utilized to investigate intracellular signaling pathways related to infection and cellular stress responses.
• Antibody & Assay Validation: Acts as a critical antigen for validating the specificity of research antibodies and ELISA kits.
• Enzymology & Kinetics: Applied in detailed kinetic studies to understand enzyme mechanism and regulation.

Basic Information

Product Name	Caspase-4
CAS No.	182762-08-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Caspase 4; CASP-4; ICE(rel)-II; ICH-2; TX; Caspase-4, Human; Inflammatory Caspase-4; Apoptotic Cysteine Protease; Interleukin-1 Beta Converting Enzyme homolog 2; Protease TX
EINECS	Contact for details

Quality Control

Our Caspase-4 is produced under stringent quality management systems to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including purity assessment by SDS-PAGE and HPLC, activity validation via fluorometric or colorimetric assays, and confirmation of identity. A detailed Certificate of Analysis (COA) documenting purity, specific activity, and storage buffer composition is provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at ≤ -20°C in small aliquots to avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use. Handle under appropriate laboratory conditions.

Specification

Item	Specification
Appearance	Lyophilized powder or clear solution
Purity (SDS-PAGE)	≥ 90%
Specific Activity	≥ [Value] units/mg
Identification (Activity)	Conforms
Endotoxin Level	< 1.0 EU/µg
Buffer Composition	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.