Description

Brimonidine-2,3-Dione is a key pharmaceutical intermediate and chemical building block. This compound is of significant commercial importance for the synthesis of active pharmaceutical ingredients (APIs) and advanced fine chemicals. It is primarily required by manufacturers in the pharmaceutical, biotechnology, and research & development sectors for producing specialized therapeutics and conducting biochemical studies.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of Brimonidine and its related analogs, which are used in ophthalmic solutions for treating glaucoma.
• Biochemical Research: Utilized as a reference standard and building block in medicinal chemistry research for developing new α-2 adrenergic receptor agonists.
• Fine Chemical Synthesis: Serves as a specialized intermediate in the multi-step synthesis of complex organic molecules for various therapeutic applications.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for GMP and non-GMP production of drug substances.

Basic Information

Product Name	Brimonidine-2,3-Dione
CAS No.	182627-95-8
Molecular Formula	C11H10BrN5O2
Molecular Weight	324.14 g/mol
Synonyms	5-Bromo-6-(imidazolidin-2-ylideneamino)quinoxalin-2,3-dione; 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-nitroquinoxalin-2-amine-2,3-dione; Brimonidine Quinoxalinedione; Brimonidine Dione Intermediate; UK-14,304-18 Dione; AGN 190342 Dione
EINECS	Contact for details

Quality Control

Our Brimonidine-2,3-Dione is manufactured under strict quality control protocols to ensure high purity and consistency. We provide comprehensive analytical data supporting identity, purity, and impurity profiles. Certificates of Analysis (COA) are available for all batches and supplied upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.