Description

(R)-Gna-A(Bz) Phosphoramidite is a high-purity, chiral phosphoramidite building block essential for the automated solid-phase synthesis of oligonucleotides. This compound matters because it enables the precise incorporation of modified nucleosides, which is critical for developing advanced therapeutic nucleic acids like antisense oligonucleotides and siRNAs with enhanced stability and target affinity. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and CROs specializing in nucleic acid chemistry and oligonucleotide-based drug discovery.

Application

• Oligonucleotide Synthesis: Key monomer for the automated solid-phase synthesis of DNA/RNA strands, particularly for introducing modified bases.
• Antisense Drug Development: Used in the production of antisense oligonucleotides (ASOs) for therapeutic applications targeting genetic diseases.
• siRNA and miRNA Synthesis: Critical for manufacturing small interfering RNA (siRNA) and microRNA (miRNA) constructs used in gene silencing research and therapeutics.
• Phosphorothioate Backbone Modification: Serves as a precursor in the synthesis of oligonucleotides with phosphorothioate linkages for improved nuclease resistance.
• Diagnostic Probe Manufacture: Employed in creating labeled probes for diagnostic assays and next-generation sequencing (NGS) platforms.
• Academic & Industrial Research: A vital reagent for research in molecular biology, biochemistry, and medicinal chemistry exploring nucleic acid function and drug mechanisms.

Basic Information

Product Name	(R)-Gna-A(Bz) Phosphoramidite
CAS No.	182625-87-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1,1-Dimethylethyl N-[(1R,2S,5R)-5-(4-aminobenzoyl)amino-2-(6-amino-9H-purin-9-yl)cyclopentyl]carbamate; (R)-Guanine Phosphoramidite; 2'-Deoxyguanosine Phosphoramidite derivative; N2-Benzoyl-2'-deoxyguanosine Phosphoramidite; dG(Bz) Phosphoramidite; 5'-Dimethoxytrityl-N2-benzoyl-2'-deoxyguanosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Guanosine phosphoramidite monomer
EINECS	Contact for details

Quality Control

Our (R)-Gna-A(Bz) Phosphoramidite is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive oligonucleotide synthesis. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in anhydrous acetonitrile, DCM

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.