Description

[Methyl-3H] Meso-Yohimbine is a tritium-labeled derivative of the yohimbane alkaloid, meso-yohimbine, specifically designed for advanced research applications. This compound is critical for high-sensitivity studies requiring precise metabolic and pharmacokinetic tracking. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) specializing in neuroscience and cardiovascular pharmacology.

Application

• Radioligand Binding Assays: Used as a high-specific-activity tracer for studying adrenergic receptor (α2-adrenoceptor) interactions and binding kinetics.
• Metabolic Pathway Tracing: Enables detailed investigation of the absorption, distribution, metabolism, and excretion (ADME) profiles of yohimbine analogs in preclinical models.
• Autoradiography Studies: Facilitates the spatial visualization and localization of receptor sites in tissue sections for neurological and cardiovascular research.
• Drug Discovery & Development: Serves as an essential tool in the screening and characterization of new compounds targeting the sympathetic nervous system.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling: Provides quantitative data for building robust models to understand drug behavior in biological systems.

Basic Information

Product Name	[Methyl-3H] Meso-Yohimbine
CAS No.	182509-57-5
Molecular Formula	C21H26N2O3 (³H-labeled)
Molecular Weight	354.45 g/mol (unlabeled base)
Synonyms	3H-Meso-Yohimbine; Tritiated Meso-Yohimbine; [³H]-Meso-Yohimbine; 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester (³H-labeled); (16α,17α)-17-Hydroxyyohimban-16-carboxylic acid methyl ester (tritiated); Rauwolscine methyl-³H; α-Yohimbine-³H; Corynanthidine methyl-³H derivative
EINECS	Contact for details

Quality Control

Every batch of [Methyl-3H] Meso-Yohimbine is manufactured and analyzed under strict quality systems. We guarantee high radiochemical purity (>97%) and specific activity as specified. Comprehensive quality control includes verification by HPLC with radiometric detection. A detailed Certificate of Analysis (COA), listing batch number, specific activity, radiochemical purity, and analytical methods, is provided with each shipment to ensure traceability and compliance with research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as supplied. Due to its highly volatile nature (tritium gas potential) and light-sensitive properties, appropriate shielding and handling in a controlled, ventilated environment are mandatory. For long-term stability, avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (HPLC & MS)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	Customizable (e.g., 60-80 Ci/mmol)
Chemical Purity (HPLC, UV)	≥ 95%
Solvent	Ethanol or custom solvent system
Concentration	1.0 mCi/mL (as specified)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.