Description

Spirotryprostatin A CAS NO 182234-25-9 is a complex, prenylated indole alkaloid originally isolated from the fungus *Aspergillus fumigatus*. This compound is of significant interest for its potent and specific biological activity as an inhibitor of mammalian cell cycle progression, particularly in the G2/M phase. It serves as a valuable reference standard and research-grade biochemical for pharmaceutical R&D, cancer research, and molecular biology studies investigating microtubule dynamics and novel anti-mitotic agents.

Application

• Pharmaceutical Research & Development: As a lead compound or reference standard in the discovery and development of novel anti-cancer therapeutics targeting cell cycle regulation.
• Cancer Biology Studies: Used in *in vitro* and cellular assays to study mechanisms of G2/M phase arrest, apoptosis induction, and microtubule assembly inhibition.
• Biochemical Pathway Analysis: A tool compound for probing specific signaling pathways and protein interactions involved in mitosis and cell proliferation.
• Academic Research: Employed in university and institutional labs for fundamental studies in chemical biology, natural product pharmacology, and medicinal chemistry.
• High-Throughput Screening (HTS): Can be utilized as a control or validation compound in screening libraries for identifying new anti-mitotic agents.
• Reference Material: Serves as a high-purity analytical standard for quality control and method development in laboratories studying fungal metabolites or prenylated alkaloids.

Basic Information

Product Name	Spirotryprostatin A
CAS No.	182234-25-9
Molecular Formula	C₂₂H₂₇N₃O₄
Molecular Weight	397.47 g/mol
Synonyms	Spirotryptostatin A; Spirotryprostatin A; (-)-Spirotryprostatin A; 6,7-Seco-6,7-didehydro-12β-hydroxy-13α-methoxyfumitremorgin C; Tryptoquivaline analogue; G2/M phase inhibitor; Fumitremorgin C derivative; Prenylated indole alkaloid
EINECS	Contact for details

Quality Control

Our Spirotryprostatin A is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results. We are committed to supplying materials that meet the stringent requirements of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. The container should be kept in a dry, well-ventilated area designated for research chemicals.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.