Description

4-(Maleimidomethyl)Cyclohexane-1-Carboxyl-Hydrazide, Trifluoroacetic Acid is a specialized heterobifunctional crosslinking reagent that combines a maleimide group with a hydrazide functionality. This compound is critically important for the site-specific conjugation of biomolecules, enabling the creation of stable, well-defined bioconjugates for advanced research and therapeutic development. It is primarily needed by researchers and manufacturers in the fields of biopharmaceuticals, antibody-drug conjugate (ADC) development, and diagnostic assay production.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Used to covalently attach cytotoxic payloads to monoclonal antibodies via the hydrazide moiety, facilitating targeted cancer therapies.
• Protein and Peptide Labeling: Enables the site-specific modification of carbonyl-containing proteins (e.g., oxidized glycoproteins) for fluorescence, biotin, or other probe attachment.
• Surface Immobilization: Functionalizes gold surfaces, chips, or nanoparticles with maleimide groups for the oriented capture of thiol-containing biomolecules in biosensor development.
• Polymer Conjugation: Serves as a key intermediate for synthesizing functionalized polymers (e.g., PEGylation agents) used in drug delivery systems to improve pharmacokinetics.
• Diagnostic Reagent Synthesis: Employed in the production of enzyme-linked immunosorbent assay (ELISA) components and other immunoassay reagents requiring stable hapten-carrier protein conjugates.
• Biomaterial Engineering: Facilitates the crosslinking of hydrogels or other biomaterials to incorporate bioactive peptides or proteins for tissue engineering applications.

Basic Information

Product Name	4-(Maleimidomethyl)Cyclohexane-1-Carboxyl-Hydrazide, Trifluoroacetic Acid
CAS No.	181148-00-5
Molecular Formula	C12H17N3O4 • C2HF3O2
Molecular Weight	Contact for details
Synonyms	4-(Maleimidomethyl)cyclohexanecarboxylic acid hydrazide TFA salt; 4-(Maleimidomethyl)-1-cyclohexanecarboxylic acid hydrazide trifluoroacetate; 4-Maleimidomethyl-cyclohexanecarboxylic acid hydrazide TFA; Maleimide-C6-Hydrazide • TFA; 4-(Maleimidomethyl)cyclohexane-1-carbohydrazide trifluoroacetic acid salt; 4-(Maleimidomethyl)cyclohexanecarbohydrazide TFA; Heterobifunctional crosslinker, maleimide-hydrazide, TFA salt
EINECS	Contact for details

Quality Control

Our 4-(Maleimidomethyl)Cyclohexane-1-Carboxyl-Hydrazide, Trifluoroacetic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee batch-to-batch consistency and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.