Description

Candesartan Acyl-Glucuronide is a key metabolite of the antihypertensive drug Candesartan, formed via hepatic glucuronidation. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced drug discovery and safety assessment programs.

Application

• Reference Standard for Bioanalysis: Serves as a critical certified reference material (CRM) for the quantification of Candesartan and its metabolites in biological matrices using LC-MS/MS and HPLC methods.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic pathways, clearance mechanisms, and pharmacokinetic profile of Candesartan cilexetil.
• Impurity Profiling and Characterization: Used to identify, quantify, and monitor this specific glucuronide conjugate as a potential impurity in active pharmaceutical ingredient (API) batches.
• Toxicological and Safety Assessment: Employed in studies to understand the safety, stability, and potential reactivity of drug metabolites.
• Regulatory Submission Support: Provides vital data for regulatory filings (e.g., with FDA, EMA) to demonstrate comprehensive understanding of a drug's metabolic fate.
• In-vitro Metabolism Studies: Utilized in incubations with hepatocytes or microsomal fractions to study enzymatic glucuronidation activity and interspecies comparisons.

Basic Information

Product Name	Candesartan Acyl-Glucuronide
CAS No.	180603-77-4
Molecular Formula	C33H34N6O8
Molecular Weight	642.66 g/mol
Synonyms	Candesartan 1-O-Acyl-β-D-Glucuronide; (2'-(1H-Tetrazol-5-yl)[1,1'-biphenyl]-4-yl)methyl 2-ethoxy-1-((2'-(1-(2-((2,3,4,5,6-pentahydroxyhexanoyl)oxy)ethyl)-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl)methyl)-1H-benzimidazole-7-carboxylate; Candesartan Acyl Glucuronide; Candesartan Metabolite; TC-01G; TC 01G
EINECS	Contact for details

Quality Control

Our Candesartan Acyl-Glucuronide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation, and impurity profiles. We adhere to relevant industry standards, and specifications can be tailored to meet specific pharmacopeial or client requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.