Description

Hiv Protease Substrate Iii-B (Native Sequence) is a specialized peptide sequence designed for the study and inhibition of HIV-1 protease enzyme activity. This compound matters as a critical research tool for developing antiviral therapies and understanding the mechanisms of HIV replication. It is needed by pharmaceutical R&D teams, academic biochemistry laboratories, and diagnostic kit manufacturers focused on virology and protease inhibitor screening.

Application

• Biochemical Research: Used as a specific substrate in enzymatic assays to study the kinetics and inhibition profile of HIV-1 protease.
• Drug Discovery & Screening: Essential for high-throughput screening (HTS) platforms to identify and evaluate novel protease inhibitor candidates.
• Mechanistic Studies: Facilitates research into the structure-activity relationship (SAR) of the HIV protease active site.
• Diagnostic Development: Serves as a key component in the development of diagnostic assays for monitoring protease activity.
• Antiviral Agent Testing: Employed in in vitro models to test the efficacy of potential antiviral compounds.
• Enzyme Characterization: Aids in the purification and functional characterization of recombinant HIV protease.

Basic Information

Product Name	Hiv Protease Substrate Iii-B (Native Sequence)
CAS No.	179912-80-2
Molecular Formula	C46H62N10O12
Molecular Weight	947.05 g/mol
Synonyms	HIV Protease Substrate III; HIV-1 Protease Substrate III-B; Acetyl-Thr-Ile-Nle-r-Nle-Gln-Arg-NH2; Ac-Thr-Ile-Nle-ψ[CH2NH]-Nle-Gln-Arg-NH2; Ac-Tle-Ile-Nle-ψ[CH2NH]-Nle-Gln-Arg-NH2; HIV PR Substrate III (reduced bond); Protease Inhibitor Substrate; HIV-1 Protease Fluorogenic Substrate analog
EINECS	Contact for details

Quality Control

Our Hiv Protease Substrate Iii-B (Native Sequence) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.