Description

Corticosterone, [1,2,6,7-3H] is a high-specific-activity, tritium-labeled derivative of the endogenous glucocorticoid hormone corticosterone. This radiolabeled compound is an essential tool for precise and sensitive research into steroid hormone metabolism, receptor binding studies, and pharmacokinetics. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) specializing in endocrinology, neurobiology, and drug discovery.

Application

• Receptor Binding Assays: Used as a tracer to study the affinity and density of glucocorticoid and mineralocorticoid receptors in competitive binding experiments.
• Metabolic Pathway Tracing: Enables the detailed mapping of corticosterone metabolism and biotransformation pathways in in vitro and in vivo studies.
• Pharmacokinetic (PK) Studies: Facilitates the sensitive quantification of corticosterone absorption, distribution, metabolism, and excretion (ADME) in preclinical models.
• Enzyme Activity Assays: Serves as a substrate for measuring the activity of key enzymes like 11β-hydroxysteroid dehydrogenases (11β-HSD).
• Stress Response Research: Critical for investigating the hypothalamic-pituitary-adrenal (HPA) axis and the physiological impact of stress.
• Analytical Method Development: Acts as an internal standard or reference material in the development and validation of LC-MS/MS and radio-HPLC methods.

Basic Information

Product Name	Corticosterone, [1,2,6,7-3H]
CAS No.	179382-80-0
Molecular Formula	C21H263H4O4 *
Molecular Weight	~ 366.5 g/mol (for unlabeled C21H30O4)
Synonyms	11β,21-Dihydroxypregn-4-ene-3,20-dione, [1,2,6,7-3H]; [3H]-Corticosterone; Tritiated Corticosterone; 4-Pregnene-11β,21-diol-3,20-dione, [1,2,6,7-3H]; NSC 9705; Kendall's compound B; Reichstein's substance H
EINECS	Contact for details

* Formula reflects tritium labeling at the 1,2,6,7 positions. Exact molecular weight depends on specific activity.

Quality Control

Every batch of our tritium-labeled corticosterone is manufactured and analyzed under strict quality systems to ensure high radiochemical purity and specific activity. Production adheres to cGMP guidelines where applicable. Comprehensive Certificates of Analysis (COA) are provided, detailing key parameters such as radiochemical purity (by HPLC), specific activity, chemical purity, and solvent composition. Our quality commitment ensures reliable and reproducible performance in your most sensitive assays.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at or below -20°C in the original solvent as supplied. Avoid repeated freeze-thaw cycles. All handling must be performed in accordance with local radiation safety regulations for tritium.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (HPLC)	Co-elutes with reference standard
Specific Activity	60 - 100 Ci/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent	Ethanol or Toluene/Ethanol mixture
Concentration	1 mCi/mL (Contact for exact concentration)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.