Description

15(R)-Hydroxy-9(Z),12(Z)-Octadecadienoic Acid is a chiral hydroxy fatty acid derivative of linoleic acid, serving as a key intermediate in the synthesis of specialized pro-resolving lipid mediators (SPMs) and other bioactive molecules. Its precise stereochemistry at the 15-position is critical for biological activity, making it a valuable building block for pharmaceutical and biochemical research. This high-purity compound is essential for scientists and manufacturers in the life sciences, nutraceutical, and advanced chemical synthesis sectors who require reliable, well-characterized raw materials.

Application

• Biochemical Research: A crucial precursor for the synthesis of specialized pro-resolving mediators (SPMs) like lipoxins and resolvins, which are studied for their role in inflammation resolution.
• Pharmaceutical Intermediates: Used in the development and production of novel therapeutic agents targeting inflammatory pathways and immune modulation.
• Nutraceutical Development: Serves as a high-value ingredient or intermediate in the formulation of advanced dietary supplements focused on metabolic and inflammatory health.
• Reference Standards: Employed as an analytical standard in chromatography (HPLC, GC) for quality control and metabolic studies in academic and industrial laboratories.
• Enzymatic & Chemical Synthesis: Acts as a substrate for enzymatic reactions (e.g., lipoxygenase studies) or as a starting material for further chemical modifications to create novel lipid analogs.

Basic Information

Product Name	15(R)-Hydroxy-9(Z),12(Z)-Octadecadienoic Acid
CAS No.	177931-23-6
Molecular Formula	C₁₈H₃₂O₃
Molecular Weight	296.45 g/mol
Synonyms	15(R)-HODE; (15R)-Hydroxy-9Z,12Z-octadecadienoic acid; 15R-Hydroxy-cis-9,cis-12-octadecadienoic acid; 15(R)-Hydroxylinoleic acid; (R)-15-Hydroxy-9,12-octadecadienoic acid; 15R-HODE; 15(R)-OH-9Z,12Z-18:2
EINECS	Contact for details

Quality Control

Our 15(R)-Hydroxy-9(Z),12(Z)-Octadecadienoic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral HPLC for enantiomeric purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing purity, chiral excess, and impurity profiles is provided with every shipment to ensure it meets the stringent requirements for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. For long-term storage, keep desiccated. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous oil or solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee (15R)
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.