Description

Ent-Aprepitant CAS NO 172822-29-6 is a high-purity enantiomer of the neurokinin-1 (NK1) receptor antagonist aprepitant. This compound is of significant value as a key intermediate and reference standard in advanced pharmaceutical research and development. It is primarily required by pharmaceutical companies and research institutions for the synthesis, analytical method development, and quality control of antiemetic drug substances.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of active pharmaceutical ingredients (APIs) targeting the NK1 receptor.
• Analytical Reference Standard: Used as a high-purity standard in HPLC, LC-MS, and other chromatographic methods for assay and impurity profiling.
• Process Research & Development (R&D): Employed in route scouting, process optimization, and scale-up studies for new chemical entities.
• Metabolite and Impurity Studies: Serves as a reference material for identifying and quantifying related substances and degradation products.
• Preclinical Research: Utilized in pharmacological and toxicological studies to understand stereospecific activity.
• Regulatory Filings: Provides essential characterization data for drug master files (DMFs) and regulatory submissions.

Basic Information

Product Name	Ent-Aprepitant
CAS No.	172822-29-6
Molecular Formula	C23H21F7N4O3
Molecular Weight	534.43 g/mol
Synonyms	(3R,5S)-5-[(2R)-(1R)-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-(morpholin-4-ylcarbonyl)morpholin-2-one; (3R,5S)-Aprepitant; Aprepitant Enantiomer; L-754030 Enantiomer; MK-0869 Enantiomer; Neurokinin 1 Receptor Antagonist Enantiomer; Emend Intermediate Enantiomer
EINECS	Contact for details

Quality Control

Our Ent-Aprepitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.