Description

(1R,2S,3S)-Aprepitant is a specific stereoisomer of the active pharmaceutical ingredient aprepitant, a potent and selective neurokinin-1 (NK1) receptor antagonist. This high-purity enantiomer is critical for ensuring the precise pharmacological activity required in advanced pharmaceutical formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development and production of antiemetic medications, particularly for the prevention of chemotherapy-induced and postoperative nausea and vomiting.

Application

• Active Pharmaceutical Ingredient (API) in the manufacture of antiemetic drugs.
• Key intermediate in the synthesis of stereochemically pure aprepitant and related NK1 antagonists.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Research and development of novel therapeutic agents targeting the NK1 receptor pathway.
• Formulation studies for oral solid dosage forms such as capsules and tablets.
• Process development and scale-up activities in cGMP manufacturing facilities.

Basic Information

Product Name	(1R,2S,3S)-Aprepitant
CAS No.	172822-28-5
Molecular Formula	C23H21F7N4O3
Molecular Weight	534.43 g/mol
Synonyms	(3-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholino]methyl]-5-oxo-4H-1,2,4-triazol-1-yl)phosphonic acid dimethyl ester; L-754030; MK-0869 isomer; Aprepitant enantiomer; Neurokinin-1 receptor antagonist; Emend® API isomer; Fosaprepitant dimeglumine precursor
EINECS	Contact for details

Quality Control

Our (1R,2S,3S)-Aprepitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and strength, suitable for pharmaceutical development. Certificates of Analysis (COA) detailing results for assay, enantiomeric excess, and related substances are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.