Description

Fosaprepitant CAS NO 172673-20-0 is a water-soluble prodrug of the neurokinin-1 (NK1) receptor antagonist aprepitant. This compound matters as a critical pharmaceutical intermediate used in the synthesis of antiemetic medications, specifically targeting the prevention of chemotherapy-induced nausea and vomiting (CINV). It is primarily needed by pharmaceutical manufacturers and research institutions engaged in the development and production of advanced oncology support therapies and related neurokinin-1 antagonist formulations.

Application

• Primary use as a key pharmaceutical intermediate in the synthesis of the antiemetic drug aprepitant.
• Manufacturing of injectable formulations for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV).
• Research and development of neurokinin-1 (NK1) receptor antagonist therapies.
• Production of combination antiemetic regimens for post-operative nausea and vomiting (PONV).
• Use in clinical trial materials for investigational antiemetic drugs.
• Reference standard for analytical method development and quality control in pharmaceutical labs.

Basic Information

Product Name	Fosaprepitant
CAS No.	172673-20-0
Molecular Formula	C23H22F7N4O6P
Molecular Weight	614.40 g/mol
Synonyms	Fosaprepitant Dimeglumine (common salt form); L-758,298; Fosaprepitant Meglumine; (2S,4S)-4-[[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluoro-2-methylphenyl)-2-(phosphonooxymethyl)-1-azabicyclo[2.2.2]octane; Aprepitant Phosphate Ester Prodrug; MK-0517; Emend® for Injection (branded product)
EINECS	Contact for details

Quality Control

Our Fosaprepitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identification by IR and NMR, and stringent control of related substances and residual solvents to ensure compliance with pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, assay, impurities, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.