Description

(+-)-Ramosetron Hydrochloride CAS NO 171967-75-2 is a potent and selective serotonin 5-HT₃ receptor antagonist. This compound is of significant interest for its potential therapeutic applications, particularly in the management of nausea and vomiting. It is a key intermediate and reference standard for pharmaceutical research and development, primarily targeting the life sciences and fine chemical synthesis sectors.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs) targeting 5-HT₃ receptors.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of ramosetron-based drug products.
• Biochemical Research: Employed in preclinical studies to investigate the pharmacology and mechanism of action of 5-HT₃ receptor antagonists.
• Antiemetic Drug Development: A key material in R&D programs focused on creating new therapies for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).
• Process Chemistry: Utilized in scaling up and optimizing synthetic routes for the commercial production of ramosetron hydrochloride.

Basic Information

Item	Detail
Product Name	(+-)-Ramosetron Hydrochloride
CAS No.	171967-75-2
Molecular Formula	C₁₇H₁₉N₃O•HCl
Molecular Weight	317.81 g/mol
Synonyms	(±)-Ramosetron HCl; Ramosetron Racemate Hydrochloride; Y-25130 Hydrochloride; 5-[(1-Methyl-1H-indol-3-yl)carbonyl]-4,5,6,7-tetrahydro-1H-benzimidazole Hydrochloride; (RS)-Ramosetron Hydrochloride; Ramosetron Hydrochloride Racemate; 1H-Benzimidazole, 4,5,6,7-tetrahydro-5-[(1-methyl-1H-indol-3-yl)carbonyl]-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our (+-)-Ramosetron Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, to ensure it meets high-grade standards suitable for research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.