Description

9-Aminodoxycycline Hydrochloride CAS NO 171807-99-1 is a chemically modified derivative of the tetracycline-class antibiotic doxycycline, characterized by the introduction of an amino group at the 9-position. This structural modification is of significant interest for the development of novel research tools and potential therapeutic agents, particularly in the fields of targeted drug delivery and photodynamic therapy. It serves as a critical pharmaceutical intermediate and research chemical for academic institutions, biotechnology firms, and pharmaceutical R&D departments focused on antibiotic research, chemical biology, and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel tetracycline-derived antibiotics and targeted conjugates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new antimicrobial agents with improved efficacy or reduced resistance.
• Chemical Biology Probes: Serves as a precursor for fluorescent or affinity-tagged probes to study bacterial ribosome interactions and tetracycline mode of action.
• Antibiotic Derivative Synthesis: Essential for creating specialized doxycycline analogs for research in anti-parasitic, anti-inflammatory, or neuroprotective applications.
• Academic & Institutional R&D: Utilized in university and government laboratory settings for fundamental research on antibiotic modification and resistance mechanisms.
• Bioconjugation Studies: The amino group provides a handle for conjugation to antibodies, polymers, or nanoparticles for targeted delivery systems.

Basic Information

Product Name	9-Aminodoxycycline Hydrochloride
CAS No.	171807-99-1
Molecular Formula	C22H25ClN3O8
Molecular Weight	494.90 g/mol
Synonyms	9-ADH; 9-Amino-Doxycycline HCl; 9-Amino-Doxycycline Hydrochloride; 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-9-amino-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Hydrochloride; 9-Amino-α-6-deoxy-5-oxytetracycline Hydrochloride; Doxycycline, 9-amino-, hydrochloride
EINECS	Contact for details

Quality Control

Our 9-Aminodoxycycline Hydrochloride is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange-yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.