Description

Uridine, 5'-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2'-o-2-Propyn-1-Yl- is a key protected nucleoside derivative, specifically designed for advanced oligonucleotide synthesis and medicinal chemistry research. This compound is critical for the controlled introduction of modified uridine units into nucleic acid sequences, enabling the development of novel therapeutics and research tools. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on antisense oligonucleotides, siRNA, and other nucleic acid-based modalities.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): Serves as a crucial phosphoramidite precursor for the automated synthesis of modified RNA strands.
• Antisense & siRNA Drug Development: Enables the site-specific incorporation of alkynyl-functionalized uridine for subsequent bioconjugation (e.g., via click chemistry) with targeting ligands, fluorophores, or other functional groups.
• Medicinal Chemistry & Prodrug Design: Used in the synthesis of nucleoside analogs where selective deprotection of the 5'-DMT and 2'-alkynyl groups is required.
• Chemical Biology Probes: Acts as a building block for creating labeled nucleotide probes to study RNA structure, function, and protein-RNA interactions.
• Academic Research: Fundamental research in nucleic acid chemistry, exploring novel modification strategies and their impact on hybridization and stability.
• Process Development: Scaling up synthesis for pre-clinical and clinical-stage therapeutic oligonucleotide candidates.

Basic Information

Item	Detail
Product Name	Uridine, 5'-o-[Bis(4-Methoxyphenyl)Phenylmethyl]-2'-o-2-Propyn-1-Yl-
CAS No.	171486-54-7
Molecular Formula	C33H32N2O8
Molecular Weight	584.62 g/mol
Synonyms	5'-O-DMT-2'-O-Propargyluridine; 2'-O-Propargyl-5'-O-(4,4'-dimethoxytrityl)uridine; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(2-propynyl)uridine; DMT-2'-O-Propargyluridine; 2'-O-Propargyl-5'-O-DMT-uridine; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propyn-1-yl-; 2'-O-(Prop-2-yn-1-yl)-5'-O-(4,4'-dimethoxytrityl)uridine
EINECS	Contact for details

Quality Control

Our production of this high-value synthetic intermediate adheres to stringent in-process controls and final release testing. Each batch is characterized by HPLC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. We provide comprehensive Certificates of Analysis (COA) with batch-specific data, ensuring traceability and consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive); containers should be sealed under an inert atmosphere and allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.