Description

Aprepitant CAS NO 170902-80-4 is a potent and selective neurokinin-1 (NK1) receptor antagonist. This compound is critical for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). It is an essential active pharmaceutical ingredient (API) for pharmaceutical manufacturers developing antiemetic formulations. Our supply ensures high purity and consistent quality for reliable downstream production.

Application

• Primary Active Pharmaceutical Ingredient (API) in antiemetic drug formulations.
• Manufacturing of oral capsules for the prevention of chemotherapy-induced nausea and vomiting (CINV).
• Key component in combination therapies for enhanced antiemetic efficacy.
• Research and development of novel neurokinin-1 receptor antagonist drugs.
• Reference standard for analytical method development and quality control in pharmaceutical labs.
• Process development and scale-up studies for generic drug manufacturing.

Basic Information

Product Name	Aprepitant
CAS No.	170902-80-4
Molecular Formula	C23H21F7N4O3
Molecular Weight	534.43 g/mol
Synonyms	MK-0869; L-754,030; 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Emend (Brand Name); CI-1041; Vofopitant
EINECS	Contact for details

Quality Control

Our Aprepitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent pharmaceutical-grade specifications, including identity, purity, and impurity profile. Certificates of Analysis (COA) are provided with every shipment, detailing results from tests such as HPLC assay, related substances, residual solvents, and heavy metals. We support compliance with cGMP, ICH Q7, and relevant pharmacopeial standards (USP/EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water Content (KF)	NMT 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	NMT 20 ppm
Sulfated Ash	NMT 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.