Description

Hanatoxin-1 is a potent, selective peptide neurotoxin originally isolated from the venom of the Chilean rose tarantula (*Grammostola rosea*). This compound is a valuable research-grade biochemical tool for studying voltage-gated potassium (Kv) channels, specifically inhibiting Kv2.1 and certain other Kv1 family channels. It is essential for neuroscientists, pharmacologists, and biochemists engaged in ion channel research, drug discovery, and neurophysiological studies. The product is supplied as a high-purity lyophilized powder, identified by CAS No. 170780-00-4.

Application

• Neuroscience Research: A critical tool for probing the structure, function, and pharmacology of voltage-gated potassium (Kv) channels, particularly Kv2.1 subtypes.
• Drug Discovery & Development: Used in high-throughput screening (HTS) assays to identify and characterize novel modulators of ion channels for therapeutic applications.
• Electrophysiology Studies: Employed in patch-clamp experiments to selectively block specific potassium currents, enabling detailed mechanistic studies of neuronal excitability and signaling.
• Biochemical & Biophysical Research: Serves as a ligand for studying toxin-channel interactions, aiding in the mapping of channel pore regions and gating mechanisms.
• Academic & Institutional Research: Supports fundamental research in universities and institutes focused on cellular physiology, channelopathies, and neurotoxicology.

Basic Information

Product Name	Hanatoxin-1
CAS No.	170780-00-4
Molecular Formula	C185H273N51O52S6
Molecular Weight	~4211.9 g/mol
Synonyms	Hanatoxin 1; HaTx-1; ω-Grammotoxin SIA; Grammostola rosea Hanatoxin-1; Voltage-gated potassium channel toxin HaTx1; ShK-like toxin HaTx1
EINECS	Contact for details

Quality Control

Our Hanatoxin-1 is produced and tested to meet stringent standards for research applications. Each batch undergoes comprehensive analysis to ensure identity, purity, and biological activity. A detailed Certificate of Analysis (COA) is provided, typically including data from HPLC, MS, and amino acid analysis. We adhere to a rigorous quality management system to ensure batch-to-batch consistency and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Biological Activity (IC50)	Specified per batch (typically nM range vs. Kv2.1)
Solubility	Soluble in aqueous buffers or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.