Description

Aprepitant CAS NO 170729-80-3 is a high-purity, small-molecule pharmaceutical active ingredient classified as a neurokinin-1 (NK1) receptor antagonist. This compound is critical for the prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV), offering significant therapeutic value in oncology support care. It is an essential raw material for pharmaceutical manufacturers developing and producing antiemetic formulations, including capsules and injectables. Our supply is characterized by stringent quality control, ensuring reliability for critical drug production processes.

Application

• Primary Pharmaceutical Ingredient: Used as the active pharmaceutical ingredient (API) in the manufacture of antiemetic drugs for CINV prevention.
• Oncology Supportive Care: Formulated in combination regimens with 5-HT3 receptor antagonists and corticosteroids for enhanced efficacy against nausea and vomiting.
• Postoperative Nausea and Vomiting (PONV): Investigated for use in preventing nausea and vomiting following surgical procedures.
• Research & Development: Serves as a key reference standard and building block in preclinical and clinical research for neurokinin pathway modulation.
• Generic Drug Manufacturing: A vital component for companies producing bioequivalent versions of branded aprepitant medications.
• Veterinary Pharmaceuticals: Potential application in developing antiemetic treatments for animals undergoing chemotherapy.

Basic Information

Product Name	Aprepitant
CAS No.	170729-80-3
Molecular Formula	C23H21F7N4O3
Molecular Weight	534.43 g/mol
Synonyms	MK-0869; L-754,030; Emend® (Brand Name); 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1H-1,2,4-triazol-3-one; Neurokinin 1 Receptor Antagonist; Antiemetic Agent
EINECS	Contact for details

Quality Control

Our Aprepitant is manufactured and tested under a quality management system designed to meet the rigorous demands of the pharmaceutical industry. Each batch is analyzed to ensure compliance with relevant pharmacopeial standards, including USP and ICH guidelines for impurities. Comprehensive testing covers identity, assay, related substances, residual solvents, and microbiological attributes. A Certificate of Analysis (COA) documenting all release specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual unknown impurity: NMT 0.10% Total impurities: NMT 0.5%
Water (Karl Fischer)	NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm
Sulfated Ash	NMT 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.