Description

n-Succinimidyl 3-(Diphenylphosphino)Propionate is a versatile heterobifunctional crosslinking reagent featuring both a phosphine group and an N-hydroxysuccinimide (NHS) ester. This compound is critical for creating stable amide bonds with primary amines while enabling subsequent conjugation via its phosphine moiety, often in Staudinger ligation or metal coordination chemistry. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, materials science, and pharmaceutical development for labeling, immobilization, and the synthesis of complex molecular architectures.

Application

• Bioconjugation and Protein Labeling: Used to attach probes, drugs, or other molecules to proteins, antibodies, and peptides via stable amide bonds, with the phosphine enabling orthogonal click chemistry or reduction.
• Surface Functionalization: Employed to modify nanoparticles, polymers, and solid supports with amine-reactive groups for subsequent immobilization of biomolecules or catalysts.
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of antibody-drug conjugates (ADCs) and targeted therapeutic agents.
• Polymer Chemistry: Acts as a crosslinker or chain-transfer agent in the synthesis of functional polymers with tailored properties.
• Staudinger Ligation: Facilitates traceless and bioorthogonal conjugation reactions between azides and the phosphine group under mild, aqueous conditions.
• Catalyst and Ligand Synthesis: Used to prepare phosphine-containing ligands for transition metal catalysis in organic synthesis.
• Diagnostic Reagent Development: Incorporated into the design of immunoassay components and biosensors.

Basic Information

Product Name	n-Succinimidyl 3-(Diphenylphosphino)Propionate
CAS No.	170278-50-9
Molecular Formula	C21H20NO4P
Molecular Weight	381.36 g/mol
Synonyms	3-(Diphenylphosphino)propionic Acid N-Succinimidyl Ester; SDPP; NHS-PDP; N-Hydroxysuccinimide Ester of 3-(Diphenylphosphino)propionic Acid; 3-(Diphenylphosphanyl)propanoic Acid 2,5-Dioxopyrrolidin-1-yl Ester; (2,5-Dioxopyrrolidin-1-yl) 3-(diphenylphosphanyl)propanoate; PDP-NHS Ester; NSC 339586
EINECS	Contact for details

Quality Control

Our n-Succinimidyl 3-(Diphenylphosphino)Propionate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research and development applications. Each lot is characterized by NMR, HPLC, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive and potentially air-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay	≥ 97%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile, dichloromethane

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.