Description

Tos-Peg5-Ch2Co2T-Butyl Ester is a specialized bifunctional PEG derivative featuring a tosylate leaving group and a protected carboxylic acid. This compound is a crucial building block in organic synthesis and bioconjugation, enabling the controlled introduction of hydrophilic polyethylene glycol (PEG) spacers. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as linker synthesis, prodrug development, and polymer modification.

Application

• Bioconjugation Linker: Serves as a heterobifunctional crosslinker for attaching drugs, proteins, or fluorescent dyes to nanoparticles, polymers, or other biomolecules.
• Prodrug Synthesis: Used to create prodrugs with enhanced solubility and controlled release profiles via the hydrolysable t-butyl ester group.
• Polymer Functionalization: Acts as a key monomer or modifier for synthesizing functionalized PEG-based polymers and hydrogels with tailored properties.
• Solid-Phase Peptide Synthesis (SPPS): Employed to introduce PEG spacers into peptide chains to improve pharmacokinetics and stability.
• Surface Modification: Utilized to PEGylate surfaces of medical devices or diagnostic tools to reduce non-specific binding and improve biocompatibility.
• Chemical Biology Probes: A versatile reagent for constructing probes used in studying biological processes and target engagement.

Basic Information

Product Name	Tos-Peg5-Ch2Co2T-Butyl Ester
CAS No.	169751-73-9
Molecular Formula	C24H40O10S
Molecular Weight	520.64 g/mol
Synonyms	1-[2-[2-[2-[2-[2-(4-Methylbenzenesulfonyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 2,2-dimethylpropanoate; Tosyl-PEG5-t-butyl ester; Tos-PEG5-COOtBu; 4-Methylbenzenesulfonic acid 2,5,8,11,14-pentaoxaheptadec-16-yl ester, 17-tert-butoxy-17-oxo-; PEG5 Tosylate t-Butyl Ester; Tos-PEG5-CH2CO2tBu; Heterobifunctional PEG derivative, Tos-PEG5-tBu ester
EINECS	Contact for details

Quality Control

Our Tos-Peg5-Ch2Co2T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.