Description

Sulfo-n-Succinimidyl 6-[3-(2-Pyridyldithio)Propionamido] Hexanoate, Sodium Salt is a heterobifunctional crosslinking reagent designed for the conjugation of biomolecules, featuring an amine-reactive NHS ester and a sulfhydryl-reactive pyridyldithiol group. This compound is critical for creating stable, cleavable linkages in antibody-drug conjugates (ADCs), protein labeling, and surface immobilization studies. It is an essential tool for researchers and manufacturers in the fields of bioconjugation, pharmaceutical development, and advanced diagnostics.

Application

• Antibody-Drug Conjugate (ADC) Development: Enables the site-specific conjugation of cytotoxic drugs to monoclonal antibodies via cleavable disulfide bonds.
• Protein-Protein Crosslinking: Used to study protein interactions or create protein complexes by linking amine and thiol groups.
• Surface Functionalization: Immobilizes proteins, peptides, or other ligands onto amine- or thiol-presenting surfaces (e.g., biosensors, microarrays).
• Fluorescent & Biotin Labeling: Conjugates fluorescent dyes or biotin tags to antibodies, enzymes, or other proteins for detection and purification.
• Nanoparticle & Liposome Conjugation: Attaches targeting ligands or therapeutic payloads to nanocarrier systems.
• Enzyme Modification: Used to modify enzymes with polymers or other molecules to alter stability, activity, or pharmacokinetics.
• Peptide Chemistry: Facilitates the synthesis of peptide conjugates and cyclic peptides.
• Diagnostic Reagent Manufacturing: A key component in the production of diagnostic kits and immunoassays.

Basic Information

Product Name	Sulfo-n-Succinimidyl 6-[3-(2-Pyridyldithio)Propionamido] Hexanoate, Sodium Salt
CAS No.	169751-10-4
Molecular Formula	C22H27N4NaO9S3
Molecular Weight	634.65 g/mol
Synonyms	Sulfo-LC-SPDP; Sulfo-Succinimidyl 6-[3'-(2-Pyridyldithio)-Propionamido]hexanoate, Sodium Salt; NHS-PEG5-SPDP, Sulfo; Sodium 6-[[3-[2-pyridinyldithio]propanoyl]amino]hexanoate 2,5-dioxo-1-pyrrolidinyl ester sulfonate; 6-((3-(2-pyridyldithio)propanamido)hexanoic acid, sulfo-NHS ester, sodium salt; Heterobifunctional Crosslinker, Sulfo-NHS-PDP; SPDP derivative, sulfonated; EZ-Link Sulfo-LC-SPDP
EINECS	Contact for details

Quality Control

Our Sulfo-n-Succinimidyl 6-[3-(2-Pyridyldithio)Propionamido] Hexanoate, Sodium Salt is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC purity analysis, NMR structural confirmation, and functional group assay, to ensure consistency and performance for critical bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO
Functional Assay (NHS Ester)	≥ 90% of theoretical
Pyridyl Disulfide Content	≥ 90% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.