Description

Caspase-3 CAS NO 169592-56-7 is a critical cysteine-aspartic protease enzyme that plays a central role in the execution phase of apoptosis, or programmed cell death. Its reliable activity and purity are essential for accurate biochemical research and high-throughput screening in drug discovery. This product is primarily utilized by researchers and scientists in the fields of oncology, neurobiology, and immunology, as well as by pharmaceutical companies developing novel therapeutics targeting apoptotic pathways.

Application

• Biochemical Research & Assay Development: Used as a key reagent in enzymatic assays to study apoptosis mechanisms and caspase activation pathways.
• Drug Discovery & Screening: Employed in high-throughput screening platforms to identify and validate potential inhibitors or activators of caspase-3 for therapeutic applications.
• Cancer Research: Essential for investigating the role of apoptosis in tumorigenesis and for evaluating the efficacy of chemotherapeutic agents.
• Neurodegenerative Disease Studies: Used in models of diseases like Alzheimer's and Parkinson's to understand neuronal cell death.
• Immunology Research: Applied in studies of immune cell regulation and death receptor-mediated apoptosis.
• Diagnostic Kit Manufacturing: Serves as a core component in the production of research-use-only (RUO) kits for detecting apoptosis.

Basic Information

Product Name	Caspase-3
CAS No.	169592-56-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Caspase 3; CPP32; Apopain; Yama; SCA-1; Cysteine protease CPP32; Caspase-3, recombinant; PARP cleavage protease; CASP3; EC 3.4.22.56
EINECS	Contact for details

Quality Control

Our Caspase-3 is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analysis to ensure high specific activity, purity, and the absence of contaminating proteases. A detailed Certificate of Analysis (COA), providing data on activity units/mg, purity level (typically by SDS-PAGE), and stability, is available for every shipment to support your research reproducibility and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. This product is hygroscopic (moisture-sensitive); always allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	Lyophilized powder or solution
Identification (Activity)	Conforms
Specific Activity	> XXXX units/mg protein
Purity (SDS-PAGE)	> 95%
Protein Concentration	Determined by Bradford or UV absorbance
Endotoxin Level	< 1.0 EU/μg
Storage Buffer	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.