Description

4-Arm PEG-NH2 (2K, 5K, 10K, 20K) is a multi-functional, amine-terminated polyethylene glycol derivative, a critical building block for advanced material synthesis. Its four reactive primary amine groups enable high-density conjugation and cross-linking, making it essential for creating sophisticated, biocompatible polymer networks. This product is vital for researchers and manufacturers in the pharmaceutical, biomedical, and nanotechnology sectors who require precise, functionalized polymers for drug delivery systems, hydrogel scaffolds, and surface modification. The CAS number for this compound is 169501-65-9.

Application

• Drug Delivery Systems: As a core component for constructing multi-arm, PEGylated drug conjugates and nanocarriers to enhance solubility, prolong circulation time, and enable targeted release.
• Bioconjugation & Protein Modification: For site-specific PEGylation of proteins, peptides, and antibodies to improve stability, reduce immunogenicity, and optimize pharmacokinetic profiles.
• Hydrogel Formation: Serving as a versatile cross-linker with multi-functional groups (e.g., NHS esters, acrylates) to create tunable, biocompatible hydrogels for tissue engineering and 3D cell culture.
• Surface Functionalization: Modifying material surfaces (e.g., nanoparticles, medical devices, biosensors) to introduce amine groups for subsequent biomolecule immobilization and to create non-fouling, hydrophilic coatings.
• Dendrimer & Star Polymer Synthesis: Acting as a central core for the divergent synthesis of complex, branched polymeric architectures with controlled molecular weight and functionality.
• Diagnostic Reagents: Used in the development of contrast agents and diagnostic probes where a multi-valent platform is needed for attaching multiple targeting or signaling moieties.

Basic Information

Product Name	4-Arm PEG-NH2 (2K, 5K, 10K, 20K)
CAS No.	169501-65-9
Molecular Formula	CnH2n+2On+1(NH2)4 (n varies by PEG chain length)
Molecular Weight	~2,000; ~5,000; ~10,000; ~20,000 g/mol (nominal)
Synonyms	4-Arm Poly(ethylene glycol) amine; Tetra-Arm PEG Amine; 4-Arm PEG Amine; Four-Arm PEG-NH2; Star PEG Amine; Multi-Arm PEG-NH2; PEG Tetraamine; α,ω-Bis-amino, 4-arm polyethylene glycol; Tetrahydroxyl-terminated PEG amine derivative
EINECS	Contact for details

Quality Control

Our 4-Arm PEG-NH2 is manufactured under strict quality management systems. Each batch is characterized using advanced analytical techniques to ensure consistent molecular weight distribution, high amine functionality, and low levels of impurities. We provide comprehensive Certificates of Analysis (COA) detailing specifications for the grade you select, supporting applications in GMP and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive). For long-term storage under inert atmosphere (argon or nitrogen), please contact us for specific recommendations. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Nominal Molecular Weight	2,000 / 5,000 / 10,000 / 20,000
Molecular Weight Distribution (Đ)	≤ 1.10 (by GPC)
Amine Value (mmol/g)	As per theoretical calculation for selected MW
Purity (HPLC)	≥ 95%
Moisture Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.